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==Crystal structure of CEACAM3==
==Crystal structure of CEACAM3==
<StructureSection load='6aw1' size='340' side='right' caption='[[6aw1]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='6aw1' size='340' side='right'caption='[[6aw1]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6aw1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AW1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AW1 FirstGlance]. <br>
<table><tr><td colspan='2'>[[6aw1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AW1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6AW1 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CEACAM3, CD66D, CGM1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6aw1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6aw1 OCA], [http://pdbe.org/6aw1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6aw1 RCSB], [http://www.ebi.ac.uk/pdbsum/6aw1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6aw1 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6aw1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6aw1 OCA], [https://pdbe.org/6aw1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6aw1 RCSB], [https://www.ebi.ac.uk/pdbsum/6aw1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6aw1 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CEAM3_HUMAN CEAM3_HUMAN]] Major granulocyte receptor mediating recognition and efficient opsonin-independent phagocytosis of CEACAM-binding microorganisms, including Neissiria, Moxarella and Haemophilus species, thus playing an important role in the clearance of pathogens by the innate immune system. Responsible for RAC1 stimulation in the course of pathogen phagocytosis.<ref>PMID:12864848</ref> <ref>PMID:14707113</ref>
[https://www.uniprot.org/uniprot/CEAM3_HUMAN CEAM3_HUMAN] Major granulocyte receptor mediating recognition and efficient opsonin-independent phagocytosis of CEACAM-binding microorganisms, including Neissiria, Moxarella and Haemophilus species, thus playing an important role in the clearance of pathogens by the innate immune system. Responsible for RAC1 stimulation in the course of pathogen phagocytosis.<ref>PMID:12864848</ref> <ref>PMID:14707113</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Bonsor, D A]]
[[Category: Large Structures]]
[[Category: Sundberg, E J]]
[[Category: Bonsor DA]]
[[Category: Cell adhesion]]
[[Category: Sundberg EJ]]
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