3foi

Fitting of gp18M crystal structure into 3D cryo-EM reconstruction of bacteriophage T4 contracted tail

spinqualitylabelsall models 3foi, resolution 16.00Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3foi is a 6 chain structure with sequence from Bpt4. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Related: 3foa, 3fo8, 3foh Gene: 18, GB AAA32541 (BPT4) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [VG18_BPT4] The contractile tail of bacteriophage T4 consists of a contractile sheath, a tube and a baseplate. 144 protomers of Gp18, arranged in 24 annuli, form the contractile tail sheath which participates in viral DNA injection into host cytoplasm. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed The contractile tail of bacteriophage T4 is a molecular machine that facilitates very high viral infection efficiency. Its major component is a tail sheath, which contracts during infection to less than half of its initial length. The sheath consists of 138 copies of the tail sheath protein, gene product (gp) 18, which surrounds the central non-contractile tail tube. The contraction of the sheath drives the tail tube through the outer membrane, creating a channel for the viral genome delivery. A crystal structure of about three quarters of gp18 has been determined and was fitted into cryo-electron microscopy reconstructions of the tail sheath before and after contraction. It was shown that during contraction, gp18 subunits slide over each other with no apparent change in their structure. The tail sheath structure of bacteriophage T4: a molecular machine for infecting bacteria.,Aksyuk AA, Leiman PG, Kurochkina LP, Shneider MM, Kostyuchenko VA, Mesyanzhinov VV, Rossmann MG EMBO J. 2009 Apr 8;28(7):821-9. Epub 2009 Feb 19. PMID:19229296 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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