2kh2: Difference between revisions

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~~{{Large structure}}~~

==Solution structure of a scFv-IL-1B complex==

== Structural highlights ==

<table><tr><td colspan='2'>[[2kh2]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human] and [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KH2 OCA]. For a guided tour on the structure components use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2KH2 FirstGlance].

<table><tr><td colspan='2'>[[2kh2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human] and [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KH2 OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=2KH2 FirstGlance].

</td></tr><tr id='gene'><td class="sblockLbl">[[Gene|Gene:]]</td><td class="sblockDat">IL1B, IL1F2 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>

</td></tr><tr id='gene'><td class="sblockLbl">[[Gene|Gene:]]</td><td class="sblockDat">IL1B, IL1F2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2kh2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kh2 OCA], [~~http~~://pdbe.org/2kh2 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2kh2 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2kh2 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2kh2 ProSAT]</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=2kh2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kh2 OCA], [https://pdbe.org/2kh2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kh2 RCSB], [https://www.ebi.ac.uk/pdbsum/2kh2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kh2 ProSAT]</td></tr>

</table>

~~{{Large structure}}~~

== Function ==

[[~~http~~://www.uniprot.org/uniprot/IL1B_HUMAN IL1B_HUMAN]] Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.<ref>PMID:3920526</ref>

[[https://www.uniprot.org/uniprot/IL1B_HUMAN IL1B_HUMAN]] Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.<ref>PMID:3920526</ref>

== Evolutionary Conservation ==

[[Image:Consurf_key_small.gif|200px|right]]

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==See Also==

*[[Antibody 3D structures|Antibody 3D structures]]

*[[Interleukin|Interleukin]]

*[[Interleukin 3D structures|Interleukin 3D structures]]

*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]

*[[3D structures of non-human antibody|3D structures of non-human antibody]]

== References ==

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</StructureSection>

[[Category: Human]]

[[Category: Large Structures]]

[[Category: Lk3 transgenic mice]]

[[Category: Carr, M D]]

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@@ Line 1: / Line 1: @@
-{{Large structure}}
 ==Solution structure of a scFv-IL-1B complex==
-<StructureSection load='2kh2' size='340' side='right' caption='[[2kh2]], [[NMR_Ensembles_of_Models | 77 NMR models]]' scene=''>
+<StructureSection load='2kh2' size='340' side='right'caption='[[2kh2]], [[NMR_Ensembles_of_Models | 77 NMR models]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2kh2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KH2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KH2 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2kh2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human] and [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KH2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KH2 FirstGlance]. <br>
-</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IL1B, IL1F2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IL1B, IL1F2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kh2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kh2 OCA], [http://pdbe.org/2kh2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2kh2 RCSB], [http://www.ebi.ac.uk/pdbsum/2kh2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2kh2 ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kh2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kh2 OCA], [https://pdbe.org/2kh2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kh2 RCSB], [https://www.ebi.ac.uk/pdbsum/2kh2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kh2 ProSAT]</span></td></tr>
 </table>
-{{Large structure}}
 == Function ==
-[[http://www.uniprot.org/uniprot/IL1B_HUMAN IL1B_HUMAN]] Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.<ref>PMID:3920526</ref>
+[[https://www.uniprot.org/uniprot/IL1B_HUMAN IL1B_HUMAN]] Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.<ref>PMID:3920526</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 32: / Line 31: @@
 ==See Also==
 *[[Antibody 3D structures|Antibody 3D structures]]
-*[[Interleukin|Interleukin]]
+*[[Interleukin 3D structures|Interleukin 3D structures]]
+*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]
+*[[3D structures of non-human antibody|3D structures of non-human antibody]]
 == References ==
 <references/>
@@ Line 38: / Line 39: @@
 </StructureSection>
 [[Category: Human]]
+[[Category: Large Structures]]
 [[Category: Lk3 transgenic mice]]
 [[Category: Carr, M D]]