6dry: Difference between revisions
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==Structural Determinants of Activation and Biased Agonism at the 5-HT2B Receptor== | |||
<StructureSection load='6dry' size='340' side='right' caption='[[6dry]], [[Resolution|resolution]] 2.92Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6dry]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DRY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DRY FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=H8D:(8beta)-N-[(2S)-1-hydroxybutan-2-yl]-6-methyl-9,10-didehydroergoline-8-carboxamide'>H8D</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dry OCA], [http://pdbe.org/6dry PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dry RCSB], [http://www.ebi.ac.uk/pdbsum/6dry PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dry ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/5HT2B_HUMAN 5HT2B_HUMAN]] This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Plays a role in the regulation of impulsive behavior. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Agegnehu, B]] | |||
[[Category: Che, T]] | [[Category: Che, T]] | ||
[[Category: | [[Category: Jin, J]] | ||
[[Category: Lansu, K]] | [[Category: Lansu, K]] | ||
[[Category: Liu, J]] | [[Category: Liu, J]] | ||
[[Category: McCorvy, J D]] | |||
[[Category: Olsen, R H.J]] | |||
[[Category: Roth, B L]] | |||
[[Category: Tribo, A R]] | |||
[[Category: Wacker, D]] | |||
[[Category: Wang, S]] | [[Category: Wang, S]] | ||
[[Category: | [[Category: Gpcr]] | ||
[[Category: | [[Category: Membrane protein]] | ||
[[Category: | [[Category: Methylergonovine]] | ||
[[Category: Setotonin receptor]] | |||
Revision as of 07:28, 29 August 2018
Structural Determinants of Activation and Biased Agonism at the 5-HT2B Receptor
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