6e4a: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6e4a is ~~ON HOLD~~

==Crystal structure of human BRD4(1) in complex with CN750==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[6e4a]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E4A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6E4A FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HRY:5-(4-{[(3-chlorophenyl)methyl]amino}-2-{4-[2-(dimethylamino)ethyl]piperazin-1-yl}quinazolin-6-yl)-1-methylpyridin-2(1H)-one'>HRY</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6e4a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e4a OCA], [http://pdbe.org/6e4a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6e4a RCSB], [http://www.ebi.ac.uk/pdbsum/6e4a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6e4a ProSAT]</span></td></tr>

</table>

== Disease ==

[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>

== Function ==

[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).

== References ==

__TOC__

</StructureSection>

[[Category: Fontano, E]]

[[Category: Lakshminarasimhan, D]]

[[Category: Suto, R K]]

[[Category: White, A]]

[[Category: Protein binding]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6e4a is ON HOLD
+==Crystal structure of human BRD4(1) in complex with CN750==
+<StructureSection load='6e4a' size='340' side='right' caption='[[6e4a]], [[Resolution|resolution]] 1.26&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6e4a]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E4A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6E4A FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HRY:5-(4-{[(3-chlorophenyl)methyl]amino}-2-{4-[2-(dimethylamino)ethyl]piperazin-1-yl}quinazolin-6-yl)-1-methylpyridin-2(1H)-one'>HRY</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6e4a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e4a OCA], [http://pdbe.org/6e4a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6e4a RCSB], [http://www.ebi.ac.uk/pdbsum/6e4a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6e4a ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
+== Function ==
+[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Fontano, E]]
+[[Category: Lakshminarasimhan, D]]
+[[Category: Suto, R K]]
+[[Category: White, A]]
+[[Category: Protein binding]]