6h3e: Difference between revisions
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==Receptor-bound Ghrelin conformation== | |||
<StructureSection load='6h3e' size='340' side='right'caption='[[6h3e]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6h3e]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6H3E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6H3E FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FKZ:octan-1-amine'>FKZ</scene></td></tr> | |||
[[Category: | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6h3e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6h3e OCA], [http://pdbe.org/6h3e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6h3e RCSB], [http://www.ebi.ac.uk/pdbsum/6h3e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6h3e ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/GHRL_HUMAN GHRL_HUMAN]] Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation. Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility (By similarity). | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Baneres, J L]] | |||
[[Category: Czaplicki, G]] | |||
[[Category: Damian, M]] | |||
[[Category: Demange, P]] | |||
[[Category: Fehrentz, J A]] | |||
[[Category: Ferre, G]] | |||
[[Category: Kadmi, C M]] | |||
[[Category: Marie, J]] | |||
[[Category: Milon, A]] | |||
[[Category: Saurel, O]] | |||
[[Category: Acyl chain]] | |||
[[Category: Addiction]] | |||
[[Category: Diabetes]] | |||
[[Category: Gpcr]] | |||
[[Category: Growth hormone secretagogue receptor]] | |||
[[Category: Hormone]] | |||
[[Category: Lipopeptide hormone]] | |||
[[Category: Neuropeptide]] | |||
[[Category: Obesity]] | |||
