Introduction to Evolutionary Conservation: Difference between revisions
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Conservation is '''expected''' for those amino acids that support the 3D structure and functions of a protein. Common examples are listed in the table below. When there is no known structural or functional explanation for conservation of an amino acid, or a cluster of amino acids, their conservation is '''unexpected'''. Such unexpected conservation may be clues for discovering new functions or structural features, e.g. through functional analysis of mutants. | Conservation is '''expected''' for those amino acids that support the 3D structure and functions of a protein. Common examples are listed in the table below. When there is no known structural or functional explanation for conservation of an amino acid, or a cluster of amino acids, their conservation is '''unexpected'''. Such unexpected conservation may be clues for discovering new functions or structural features, e.g. through functional analysis of mutants. | ||
<table><tr><td colspan="2"><center> | <table class="wikitable"><tr> | ||
<td colspan="2"><center> | |||
Expected Evolutionary Conservation | Expected Evolutionary Conservation | ||
</center> | |||
</td></tr><tr><td> | </td></tr><tr><td> | ||
Amino Acids | Amino Acids | ||
</td><td> | </td><td> | ||
Reason for Conservation | Reason for Conservation | ||
</tr></td></table> | </td></tr><tr><td> | ||
Gly, Pro in turns between helices or beta strands | |||
</td><td> | |||
Required for protein folding | |||
</td></tr></table> | |||
{{Clear}} | {{Clear}} | ||
