6e00: Difference between revisions

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'''Unreleased structure'''


The entry 6e00 is ON HOLD  until Paper Publication
==Structure of a N-Me-p-iodo-D-Phe1,N-Me-D-Gln4,Lys10-teixobactin analogue==
<StructureSection load='6e00' size='340' side='right' caption='[[6e00]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6e00]] is a 32 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E00 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6E00 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=28J:D-ALLOISOLEUCINE'>28J</scene>, <scene name='pdbligand=DTH:D-THREONINE'>DTH</scene>, <scene name='pdbligand=HJV:'>HJV</scene>, <scene name='pdbligand=HJY:'>HJY</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6e00 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e00 OCA], [http://pdbe.org/6e00 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6e00 RCSB], [http://www.ebi.ac.uk/pdbsum/6e00 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6e00 ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
This paper describes the X-ray crystallographic structure of a derivative of the antibiotic teixobactin and shows that its supramolecular assembly through the formation of antiparallel beta-sheets creates binding sites for oxyanions. An active derivative of teixobactin containing lysine in place of allo-enduracididine assembles to form amyloid-like fibrils, which are observed through a thioflavin T fluorescence assay and by transmission electron microscopy. A homologue, bearing an N-methyl substituent, to attenuate fibril formation, and an iodine atom, to facilitate X-ray crystallographic phase determination, crystallizes as double helices of beta-sheets that bind sulfate anions. beta-Sheet dimers are key subunits of these assemblies, with the N-terminal methylammonium group of one monomer and the C-terminal macrocycle of the other monomer binding each anion. These observations suggest a working model for the mechanism of action of teixobactin, in which the antibiotic assembles and the assemblies bind lipid II and related bacterial cell wall precursors on the surface of Gram-positive bacteria.


Authors: Nowick, J.S., Yang, H., Wierzbicki, M.
X-ray Crystallographic Structure of a Teixobactin Derivative Reveals Amyloid-Like Assembly.,Yang H, Wierzbicki M, Du Bois DR, Nowick JS J Am Chem Soc. 2018 Oct 8. doi: 10.1021/jacs.8b07709. PMID:30296063<ref>PMID:30296063</ref>


Description: Structure of a N-Me-p-iodo-D-Phe1,N-Me-D-Gln4,Lys10-teixobactin analogue
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
[[Category: Nowick, J.S]]
<div class="pdbe-citations 6e00" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Nowick, J S]]
[[Category: Wierzbicki, M]]
[[Category: Yang, H]]
[[Category: Yang, H]]
[[Category: Wierzbicki, M]]
[[Category: Antibiotic]]
[[Category: Fibril]]
[[Category: Helix]]
[[Category: Teixobactin]]
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