6e7i: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 6e7i is ~~ON HOLD until Paper Publication~~

==Human ppGalNAcT2 I253A/L310A Mutant with EA2 and UDP==

~~Authors~~: ~~Bertozzi~~, C.R., ~~Schumann~~, B., ~~Agbay~~, A.J.

== Structural highlights ==

<table><tr><td colspan='2'>[[6e7i]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E7I OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6E7I FirstGlance].

~~Description~~: ~~Human ppGalNAcT2 I253A~~/~~L310A Mutant with~~ EA2 ~~and UDP~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Polypeptide_N-acetylgalactosaminyltransferase Polypeptide N-acetylgalactosaminyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.41 2.4.1.41] </td></tr>

[[Category: Agbay, A.J]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6e7i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e7i OCA], [http://pdbe.org/6e7i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6e7i RCSB], [http://www.ebi.ac.uk/pdbsum/6e7i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6e7i ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/GALT2_HUMAN GALT2_HUMAN]] Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b. Probably involved in O-linked glycosylation of the immunoglobulin A1 (IgA1) hinge region.<ref>PMID:9295285</ref> <ref>PMID:12438318</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Polypeptide N-acetylgalactosaminyltransferase]]

[[Category: Agbay, A J]]

[[Category: Bertozzi, C R]]

[[Category: Schumann, B]]

[[Category: ~~Bertozzi, C.R~~]]

[[Category: Bump-hole]]

[[Category: Galnac]]

[[Category: Glycosylation]]

[[Category: Glycosyltransferase]]

[[Category: Transferase]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6e7i is ON HOLD  until Paper Publication
+==Human ppGalNAcT2 I253A/L310A Mutant with EA2 and UDP==
+<StructureSection load='6e7i' size='340' side='right'caption='[[6e7i]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
-Authors: Bertozzi, C.R., Schumann, B., Agbay, A.J.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6e7i]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E7I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6E7I FirstGlance]. <br>
-Description: Human ppGalNAcT2 I253A/L310A Mutant with EA2 and UDP
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Polypeptide_N-acetylgalactosaminyltransferase Polypeptide N-acetylgalactosaminyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.41 2.4.1.41] </span></td></tr>
-[[Category: Agbay, A.J]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6e7i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e7i OCA], [http://pdbe.org/6e7i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6e7i RCSB], [http://www.ebi.ac.uk/pdbsum/6e7i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6e7i ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/GALT2_HUMAN GALT2_HUMAN]] Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b. Probably involved in O-linked glycosylation of the immunoglobulin A1 (IgA1) hinge region.<ref>PMID:9295285</ref> <ref>PMID:12438318</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Polypeptide N-acetylgalactosaminyltransferase]]
+[[Category: Agbay, A J]]
+[[Category: Bertozzi, C R]]
 [[Category: Schumann, B]]
-[[Category: Bertozzi, C.R]]
+[[Category: Bump-hole]]
+[[Category: Galnac]]
+[[Category: Glycosylation]]
+[[Category: Glycosyltransferase]]
+[[Category: Transferase]]