6e9d: Difference between revisions

{{Large structure}}

==Sub-2 Angstrom Ewald Curvature-Corrected Single-Particle Cryo-EM Reconstruction of AAV-2 L336C==

<table><tr><td colspan='2'>[[6e9d]] is a 60 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E9D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6E9D FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6e9d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e9d OCA], [http://pdbe.org/6e9d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6e9d RCSB], [http://www.ebi.ac.uk/pdbsum/6e9d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6e9d ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/CAPSD_AAV2S CAPSD_AAV2S]] Capsid protein self-assembles to form an icosahedral capsid with a T=1 symmetry, about 22 nm in diameter, and consisting of 60 copies of three size variants of the capsid protein VP1, VP2 and VP3 which differ in their N-terminus. The capsid encapsulates the genomic ssDNA. Binds to host cell heparan sulfate and uses host ITGA5-ITGB1 as coreceptor on the cell surface to provide virion attachment to target cell. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Binding to the host receptor also induces capsid rearrangements leading to surface exposure of VP1 N-terminus, specifically its phospholipase A2-like region and putative nuclear localization signal(s). VP1 N-terminus might serve as a lipolytic enzyme to breach the endosomal membrane during entry into host cell and might contribute to virus transport to the nucleus.<ref>PMID:10684294</ref> <ref>PMID:11961250</ref> <ref>PMID:16940508</ref> <ref>PMID:9445046</ref> 

[[Category: Agbandje-McKenna, M]]

[[Category: Baker, T S]]

[[Category: Hull, J A]]

[[Category: Tan, Y Z]]

[[Category: Aav-2 l336c]]

[[Category: Virus like particle]]