6h5t: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6h5t is ~~ON HOLD~~ ~~until Paper Publication~~

==Intersectin SH3A short isoform==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[6h5t]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6H5T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6H5T FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7PG:2,5,8,11,14,17,20,23-OCTAOXAPENTACOSAN-25-OL'>7PG</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6h5t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6h5t OCA], [http://pdbe.org/6h5t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6h5t RCSB], [http://www.ebi.ac.uk/pdbsum/6h5t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6h5t ProSAT]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/ITSN1_HUMAN ITSN1_HUMAN]] Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1.<ref>PMID:11744688</ref> <ref>PMID:22648170</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Driller, J H]]

[[Category: Freund, C]]

[[Category: Gerth, F]]

[[Category: Loll, B]]

[[Category: Wahl, M C]]

[[Category: Endocytosis]]

[[Category: Intersectin 1]]

[[Category: Sh3 domain]]

[[Category: Splice isoform]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6h5t is ON HOLD  until Paper Publication
+==Intersectin SH3A short isoform==
+<StructureSection load='6h5t' size='340' side='right' caption='[[6h5t]], [[Resolution|resolution]] 1.69&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6h5t]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6H5T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6H5T FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7PG:2,5,8,11,14,17,20,23-OCTAOXAPENTACOSAN-25-OL'>7PG</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6h5t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6h5t OCA], [http://pdbe.org/6h5t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6h5t RCSB], [http://www.ebi.ac.uk/pdbsum/6h5t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6h5t ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/ITSN1_HUMAN ITSN1_HUMAN]] Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1.<ref>PMID:11744688</ref> <ref>PMID:22648170</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Driller, J H]]
+[[Category: Freund, C]]
+[[Category: Gerth, F]]
+[[Category: Loll, B]]
+[[Category: Wahl, M C]]
+[[Category: Endocytosis]]
+[[Category: Intersectin 1]]
+[[Category: Sh3 domain]]
+[[Category: Splice isoform]]