2ot8: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
Line 1: Line 1:
[[Image:2ot8.gif|left|200px]]
[[Image:2ot8.gif|left|200px]]


{{Structure
<!--
|PDB= 2ot8 |SIZE=350|CAPTION= <scene name='initialview01'>2ot8</scene>, resolution 3.1&Aring;
The line below this paragraph, containing "STRUCTURE_2ot8", creates the "Structure Box" on the page.
|SITE=
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
|LIGAND=
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
|ACTIVITY=
or leave the SCENE parameter empty for the default display.
|GENE= TNPO1, KPNB2, MIP1, TRN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), HNRPM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
-->
|DOMAIN=
{{STRUCTURE_2ot8|  PDB=2ot8 |  SCENE= }}  
|RELATEDENTRY=[[1qbk|1qbk]], [[2h4m|2h4m]]
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ot8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ot8 OCA], [http://www.ebi.ac.uk/pdbsum/2ot8 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ot8 RCSB]</span>
}}


'''Karyopherin Beta2/Transportin-hnRNPM NLS Complex'''
'''Karyopherin Beta2/Transportin-hnRNPM NLS Complex'''
Line 27: Line 24:
[[Category: Cansizoglu, A E.]]
[[Category: Cansizoglu, A E.]]
[[Category: Chook, Y M.]]
[[Category: Chook, Y M.]]
[[Category: heat repeat]]
[[Category: Heat repeat]]
[[Category: karyopherin]]
[[Category: Karyopherin]]
[[Category: nuclear import complex]]
[[Category: Nuclear import complex]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 11:36:28 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:22:43 2008''

Revision as of 08:36, 4 May 2008

File:2ot8.gif

Template:STRUCTURE 2ot8

Karyopherin Beta2/Transportin-hnRNPM NLS Complex


Overview

Kapbeta2 (also called transportin) recognizes PY nuclear localization signal (NLS), a new class of NLS with a R/H/Kx((2-5))PY motif. Here we show that Kapbeta2 complexes containing hydrophobic and basic PY-NLSs, as classified by the composition of an additional N-terminal motif, converge in structure only at consensus motifs, which explains ligand diversity. On the basis of these data and complementary biochemical analyses, we designed a Kapbeta2-specific nuclear import inhibitor, M9M.

About this Structure

2OT8 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure-based design of a pathway-specific nuclear import inhibitor., Cansizoglu AE, Lee BJ, Zhang ZC, Fontoura BM, Chook YM, Nat Struct Mol Biol. 2007 May;14(5):452-4. Epub 2007 Apr 15. PMID:17435768 Page seeded by OCA on Sun May 4 11:36:28 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=2ot8&oldid=510423"