6eb6: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6eb6 is ~~ON HOLD~~ ~~until Paper Publication~~

==Crystal structure of BAX W139A monomer==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[6eb6]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EB6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EB6 FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6eb6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6eb6 OCA], [http://pdbe.org/6eb6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6eb6 RCSB], [http://www.ebi.ac.uk/pdbsum/6eb6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6eb6 ProSAT]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/BAX_HUMAN BAX_HUMAN]] Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.<ref>PMID:8358790</ref> <ref>PMID:10772918</ref> <ref>PMID:8521816</ref> <ref>PMID:16113678</ref> <ref>PMID:18948948</ref> <ref>PMID:21199865</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Robin, A Y]]

[[Category: Apoptosis]]

[[Category: Bax]]

[[Category: Inactive monomer]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6eb6 is ON HOLD  until Paper Publication
+==Crystal structure of BAX W139A monomer==
+<StructureSection load='6eb6' size='340' side='right'caption='[[6eb6]], [[Resolution|resolution]] 2.02&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6eb6]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EB6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EB6 FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6eb6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6eb6 OCA], [http://pdbe.org/6eb6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6eb6 RCSB], [http://www.ebi.ac.uk/pdbsum/6eb6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6eb6 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/BAX_HUMAN BAX_HUMAN]] Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.<ref>PMID:8358790</ref> <ref>PMID:10772918</ref> <ref>PMID:8521816</ref> <ref>PMID:16113678</ref> <ref>PMID:18948948</ref> <ref>PMID:21199865</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Robin, A Y]]
+[[Category: Apoptosis]]
+[[Category: Bax]]
+[[Category: Inactive monomer]]