2p1l: Difference between revisions
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'''Structure of the Bcl-XL:Beclin 1 complex''' | '''Structure of the Bcl-XL:Beclin 1 complex''' | ||
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[[Category: Oberstein, A L.]] | [[Category: Oberstein, A L.]] | ||
[[Category: Shi, Y.]] | [[Category: Shi, Y.]] | ||
[[Category: | [[Category: Apoptosis]] | ||
[[Category: | [[Category: Autophagy]] | ||
[[Category: | [[Category: Bcl]] | ||
[[Category: | [[Category: Beclin]] | ||
[[Category: | [[Category: Bh3 domain]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 12:08:53 2008'' | |||
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Revision as of 09:08, 4 May 2008
Structure of the Bcl-XL:Beclin 1 complex
Overview
Bcl-2 family proteins are key regulators of apoptosis and have recently been shown to modulate autophagy. The tumor suppressor Beclin 1 has been proposed to coordinate both apoptosis and autophagy through direct interaction with anti-apoptotic family members Bcl-2 and/or Bcl-X(L). However, the molecular basis for this interaction remains enigmatic. Here we report that Beclin 1 contains a conserved BH3 domain, which is both necessary and sufficient for its interaction with Bcl-X(L). We also report the crystal structure of a Beclin BH3 peptide in complex with Bcl-X(L) at 2.5A resolution. Reminiscent of previously determined Bcl-X(L)-BH3 structures, the amphipathic BH3 helix of Beclin 1 bound to a conserved hydrophobic groove of Bcl-X(L). These results define Beclin 1 as a novel BH3-only protein, implying that Beclin 1 may have a direct role in initiating apoptotic signaling. We propose that this putative apoptotic function may be linked to the ability of Beclin 1 to suppress tumor formation in mammals.
About this Structure
2P1L is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein., Oberstein A, Jeffrey PD, Shi Y, J Biol Chem. 2007 Apr 27;282(17):13123-32. Epub 2007 Mar 2. PMID:17337444 Page seeded by OCA on Sun May 4 12:08:53 2008
