2p22: Difference between revisions

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[[Image:2p22.jpg|left|200px]]
[[Image:2p22.jpg|left|200px]]


{{Structure
<!--
|PDB= 2p22 |SIZE=350|CAPTION= <scene name='initialview01'>2p22</scene>, resolution 2.70&Aring;
The line below this paragraph, containing "STRUCTURE_2p22", creates the "Structure Box" on the page.
|SITE=
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
|ACTIVITY=
or leave the SCENE parameter empty for the default display.
|GENE= VPS23 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]), VPT28 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]), VPS37 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]), Mvb12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])
-->
|DOMAIN=
{{STRUCTURE_2p22| PDB=2p22  | SCENE= }}  
|RELATEDENTRY=[[2f66|2F66]], [[2f6m|2F6M]], [[2caz|2CAZ]], [[|]], [[2j9v|2J9V]], [[2j9u|2J9U]]
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p22 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p22 OCA], [http://www.ebi.ac.uk/pdbsum/2p22 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2p22 RCSB]</span>
}}


'''Structure of the Yeast ESCRT-I Heterotetramer Core'''
'''Structure of the Yeast ESCRT-I Heterotetramer Core'''
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[[Category: Hurley, J H.]]
[[Category: Hurley, J H.]]
[[Category: Kostelansky, MS]]
[[Category: Kostelansky, MS]]
[[Category: endosomal sorting complex required for transport]]
[[Category: Endosomal sorting complex required for transport]]
[[Category: endosome]]
[[Category: Endosome]]
[[Category: escrt protein complex]]
[[Category: Escrt protein complex]]
[[Category: escrt-i]]
[[Category: Escrt-i]]
[[Category: mvb12]]
[[Category: Mvb12]]
[[Category: trafficking complex]]
[[Category: Trafficking complex]]
[[Category: tsg101]]
[[Category: Tsg101]]
[[Category: ubiquitin]]
[[Category: Ubiquitin]]
[[Category: vacuolar protein sorting]]
[[Category: Vacuolar protein sorting]]
[[Category: vps23]]
[[Category: Vps23]]
[[Category: vps28]]
[[Category: Vps28]]
[[Category: vps37]]
[[Category: Vps37]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 12:10:32 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:27:23 2008''

Revision as of 09:10, 4 May 2008

File:2p22.jpg

Template:STRUCTURE 2p22

Structure of the Yeast ESCRT-I Heterotetramer Core


Overview

The endosomal sorting complex required for transport-I (ESCRT-I) complex, which is conserved from yeast to humans, directs the lysosomal degradation of ubiquitinated transmembrane proteins and the budding of the HIV virus. Yeast ESCRT-I contains four subunits, Vps23, Vps28, Vps37, and Mvb12. The crystal structure of the heterotetrameric ESCRT-I complex reveals a highly asymmetric complex of 1:1:1:1 subunit stoichiometry. The core complex is nearly 18 nm long and consists of a headpiece attached to a 13 nm stalk. The stalk is important for cargo sorting by ESCRT-I and is proposed to serve as a spacer regulating the correct disposition of cargo and other ESCRT components. Hydrodynamic constraints and crystallographic structures were used to generate a model of intact ESCRT-I in solution. The results show how ESCRT-I uses a combination of a rigid stalk and flexible tethers to interact with lipids, cargo, and other ESCRT complexes over a span of approximately 25 nm.

About this Structure

2P22 is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Molecular architecture and functional model of the complete yeast ESCRT-I heterotetramer., Kostelansky MS, Schluter C, Tam YY, Lee S, Ghirlando R, Beach B, Conibear E, Hurley JH, Cell. 2007 May 4;129(3):485-98. Epub 2007 Apr 19. PMID:17442384 Page seeded by OCA on Sun May 4 12:10:32 2008

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