Nitrogenase: Difference between revisions
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For these reasons, binding of Fe protein to FeMo protein results in hydrolysis of ATP. Additionally, the 4Fe:4S cluster is lowered close enough to the metal-sulfur clusters of the FeMo protein that electron transfer can occur. All three clusters found in the Fe protein-FeMo protein complex can be seen <scene name='Sandbox_10/1n2c_clusters/2'>here</scene>. Once the electrons have passed from the 4Fe:4S cluster of the Fe protein to the 8Fe:7S cluster of the FeMo protein, they then transfer to the 7Fe:Mo:9S:homocitrate:X cluster where X is an unidentified light atom. It is at this cluster where reduction of N<sub>2</sub> and H<sup>+</sup> occur. The exact mechanism of reduction, however, is still unknown. | For these reasons, binding of Fe protein to FeMo protein results in hydrolysis of ATP. Additionally, the 4Fe:4S cluster is lowered close enough to the metal-sulfur clusters of the FeMo protein that electron transfer can occur. All three clusters found in the Fe protein-FeMo protein complex can be seen <scene name='Sandbox_10/1n2c_clusters/2'>here</scene>. Once the electrons have passed from the 4Fe:4S cluster of the Fe protein to the 8Fe:7S cluster of the FeMo protein, they then transfer to the 7Fe:Mo:9S:homocitrate:X cluster where X is an unidentified light atom. It is at this cluster where reduction of N<sub>2</sub> and H<sup>+</sup> occur. The exact mechanism of reduction, however, is still unknown. | ||
==3D structure of Nitrogenase== | |||
[[Nitrogenase 3D structures]] | |||
</StructureSection> | </StructureSection> | ||
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**[[4xpi]], [[5cx1]] - AvNase + (mutant) subunit [CFe7MoS9 Fe8S7]<br /> | **[[4xpi]], [[5cx1]] - AvNase + (mutant) subunit [CFe7MoS9 Fe8S7]<br /> | ||
**[[4tku]], [[5bvg]] - AvNase α+β subunit [CFe7MoS9 Fe8S7 Fe2]<br /> | **[[4tku]], [[5bvg]] - AvNase α+β subunit [CFe7MoS9 Fe8S7 Fe2]<br /> | ||
**[[6o7o]], [[6o7m]], [[6o7l]], [[6o7p]], [[6o7q]], [[6o7r]] - AvNase + (mutant) subunit [CFe7MoS9 Fe8S7 Fe2]<br /> | |||
**[[6o7s]] - AvNase + (mutant) subunit [CFe7MoS9 Fe6S7 Fe2]<br /> | |||
**[[6op4]] - AvNase + subunit [CFe7MoS9 Fe8S7 Mg] <br /> | |||
**[[4tkv]], [[5bvh]]- AvNase α+β subunit [CFe7MoS9 Fe8S7 Fe2] + CO <br /> | **[[4tkv]], [[5bvh]]- AvNase α+β subunit [CFe7MoS9 Fe8S7 Fe2] + CO <br /> | ||
**[[6op1]] - AvNase + subunit [CFe7MoS9 Fe8S7 Mg] + CO <br /> | |||
**[[6op2]], [[60p3]] - AvNase + subunit [CFe7MoS9 Fe8S7 Se] + <br /> | |||
**[[4wza]] - AvNase α+β subunit [CFe7MoS9 Fe8S7 Fe4S4 Fe2] + ADP + ACP<br /> | **[[4wza]] - AvNase α+β subunit [CFe7MoS9 Fe8S7 Fe4S4 Fe2] + ADP + ACP<br /> | ||
**[[4wzb]] - AvNase α+β subunit [CFe7MoS9 Fe8S7 Fe4S4 Fe2] + ACP<br /> | **[[4wzb]] - AvNase α+β subunit [CFe7MoS9 Fe8S7 Fe4S4 Fe2] + ACP<br /> | ||
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**[[2c8v]] – AvNase iron protein 1 [FeS]<br /> | **[[2c8v]] – AvNase iron protein 1 [FeS]<br /> | ||
**[[1g1m]], [[1g5p]], [[2nip]] | **[[1g1m]], [[1g5p]], [[2nip]], [[6o0b]], [[6n4k]], [[6n4j]] - AvNase iron protein 1 [Fe4S4]<br /> | ||
**[[1fp6]], [[1nip]], [[6n4m]], [[6n4l] - AvNase iron protein 1 [Fe4S4] + ADP<br /> | |||
**[[1fp6]], [[1nip]] - AvNase iron protein 1 [Fe4S4] + ADP<br /> | |||
**[[1xcp]], [[1xd8]], [[1xdb]], [[1rw4]], [[1de0]] - AvNase iron protein 1 (mutant) [Fe4S4]<br /> | **[[1xcp]], [[1xd8]], [[1xdb]], [[1rw4]], [[1de0]] - AvNase iron protein 1 (mutant) [Fe4S4]<br /> | ||
**[[6q93]] - AvNase iron protein 1 [Fe4S4] + MgADP<br /> | |||
**[[1xd9]] - AvNase iron protein 1 (mutant) [Fe4S4] + MgADP<br /> | **[[1xd9]] - AvNase iron protein 1 (mutant) [Fe4S4] + MgADP<br /> | ||
**[[1cp2]] - CpNase iron protein 1 [Fe4S4] <br /> | |||
**[[6nzj]] - Nase iron protein 1 [Fe4S4] – ''Methanosarcina acetivorans''<br /> | |||
*Nase V-Fe protein | *Nase V-Fe protein | ||
