2o3o: Difference between revisions

Revision as of 15:59, 8 June 2021

Crystal Structure of the sensor histidine kinase regulator YycI from Bacillus subtitlis

Structural highlights

2o3o is a 12 chain structure with sequence from "vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	CL
NonStd Res:	MSE
Gene:	yycI ("Vibrio subtilis" Ehrenberg 1835)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[YYCI_BACSU] Together with YycH, regulates the activity of the two-component system YycF/YycG.^[1] ^[2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

YycI and YycH are two membrane-anchored periplasmic proteins that regulate the essential Bacillus subtilis YycG histidine kinase through direct interaction. Here we present the crystal structure of YycI at a 2.9-A resolution. YycI forms a dimer, and remarkably the structure resembles that of the two C-terminal domains of YycH despite nearly undetectable sequence homology (10%) between the two proteins.

The crystal structure of Bacillus subtilis YycI reveals a common fold for two members of an unusual class of sensor histidine kinase regulatory proteins.,Santelli E, Liddington RC, Mohan MA, Hoch JA, Szurmant H J Bacteriol. 2007 Apr;189(8):3290-5. Epub 2007 Feb 16. PMID:17307848^[3]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Szurmant H, Mohan MA, Imus PM, Hoch JA. YycH and YycI interact to regulate the essential YycFG two-component system in Bacillus subtilis. J Bacteriol. 2007 Apr;189(8):3280-9. Epub 2007 Feb 16. PMID:17307850 doi:https://dx.doi.org/10.1128/JB.01936-06
↑ Szurmant H, Bu L, Brooks CL 3rd, Hoch JA. An essential sensor histidine kinase controlled by transmembrane helix interactions with its auxiliary proteins. Proc Natl Acad Sci U S A. 2008 Apr 15;105(15):5891-6. doi:, 10.1073/pnas.0800247105. Epub 2008 Apr 11. PMID:18408157 doi:https://dx.doi.org/10.1073/pnas.0800247105
↑ Santelli E, Liddington RC, Mohan MA, Hoch JA, Szurmant H. The crystal structure of Bacillus subtilis YycI reveals a common fold for two members of an unusual class of sensor histidine kinase regulatory proteins. J Bacteriol. 2007 Apr;189(8):3290-5. Epub 2007 Feb 16. PMID:17307848 doi:10.1128/JB.01937-06

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OCA

[1] Szurmant H, Mohan MA, Imus PM, Hoch JA. YycH and YycI interact to regulate the essential YycFG two-component system in Bacillus subtilis. J Bacteriol. 2007 Apr;189(8):3280-9. Epub 2007 Feb 16. PMID:17307850 doi:https://dx.doi.org/10.1128/JB.01936-06

[2] Szurmant H, Bu L, Brooks CL 3rd, Hoch JA. An essential sensor histidine kinase controlled by transmembrane helix interactions with its auxiliary proteins. Proc Natl Acad Sci U S A. 2008 Apr 15;105(15):5891-6. doi:, 10.1073/pnas.0800247105. Epub 2008 Apr 11. PMID:18408157 doi:https://dx.doi.org/10.1073/pnas.0800247105

[3] Santelli E, Liddington RC, Mohan MA, Hoch JA, Szurmant H. The crystal structure of Bacillus subtilis YycI reveals a common fold for two members of an unusual class of sensor histidine kinase regulatory proteins. J Bacteriol. 2007 Apr;189(8):3290-5. Epub 2007 Feb 16. PMID:17307848 doi:10.1128/JB.01937-06

[1]

[2]

[3]

@@ Line 1: / Line 1: @@
 ==Crystal Structure of the sensor histidine kinase regulator YycI from Bacillus subtitlis==
-<StructureSection load='2o3o' size='340' side='right' caption='[[2o3o]], [[Resolution|resolution]] 2.89&Aring;' scene=''>
+<StructureSection load='2o3o' size='340' side='right'caption='[[2o3o]], [[Resolution|resolution]] 2.89&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2o3o]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O3O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2O3O FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2o3o]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O3O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2O3O FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
 <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">yycI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "Vibrio subtilis" Ehrenberg 1835])</td></tr>
+<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">yycI ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "Vibrio subtilis" Ehrenberg 1835])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2o3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o3o OCA], [http://pdbe.org/2o3o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2o3o RCSB], [http://www.ebi.ac.uk/pdbsum/2o3o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2o3o ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2o3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o3o OCA], [https://pdbe.org/2o3o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2o3o RCSB], [https://www.ebi.ac.uk/pdbsum/2o3o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2o3o ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/YYCI_BACSU YYCI_BACSU]] Together with YycH, regulates the activity of the two-component system YycF/YycG.<ref>PMID:17307850</ref> <ref>PMID:18408157</ref>
+[[https://www.uniprot.org/uniprot/YYCI_BACSU YYCI_BACSU]] Together with YycH, regulates the activity of the two-component system YycF/YycG.<ref>PMID:17307850</ref> <ref>PMID:18408157</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 35: / Line 35: @@
 </StructureSection>
 [[Category: Vibrio subtilis ehrenberg 1835]]
+[[Category: Large Structures]]
 [[Category: Liddington, R C]]
 [[Category: Santelli, E]]
 [[Category: Signaling protein]]
 [[Category: Two-component system]]

2o3o: Difference between revisions

Revision as of 15:59, 8 June 2021

Crystal Structure of the sensor histidine kinase regulator YycI from Bacillus subtitlis

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

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