6eaz: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6eaz is ~~ON HOLD~~ ~~until Paper Publication~~

==Apo structure of the mitochondrial calcium uniporter protein MICU2==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[6eaz]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EAZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EAZ FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6eaz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6eaz OCA], [http://pdbe.org/6eaz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6eaz RCSB], [http://www.ebi.ac.uk/pdbsum/6eaz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6eaz ProSAT]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/MICU2_MOUSE MICU2_MOUSE]] Key regulator of mitochondrial calcium uniporter (MCU) required to limit calcium uptake by MCU when cytoplasmic calcium is low (PubMed:23409044, PubMed:24560927). MICU1 and MICU2 form a disulfide-linked heterodimer that stimulate and inhibit MCU activity, depending on the concentration of calcium (PubMed:24560927). MICU2 acts as a gatekeeper of MCU that senses calcium level via its EF-hand domains: prevents channel opening at resting Ca(2+), avoiding energy dissipation and cell-death triggering (PubMed:24560927).<ref>PMID:23409044</ref> <ref>PMID:24560927</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Grabarek, Z]]

[[Category: Kamer, K J]]

[[Category: Calcium]]

[[Category: Channel]]

[[Category: Ef hand]]

[[Category: Metal binding protein]]

[[Category: Mitochondria]]

[[Category: Uniporter]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6eaz is ON HOLD  until Paper Publication
+==Apo structure of the mitochondrial calcium uniporter protein MICU2==
+<StructureSection load='6eaz' size='340' side='right' caption='[[6eaz]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6eaz]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EAZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EAZ FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6eaz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6eaz OCA], [http://pdbe.org/6eaz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6eaz RCSB], [http://www.ebi.ac.uk/pdbsum/6eaz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6eaz ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/MICU2_MOUSE MICU2_MOUSE]] Key regulator of mitochondrial calcium uniporter (MCU) required to limit calcium uptake by MCU when cytoplasmic calcium is low (PubMed:23409044, PubMed:24560927). MICU1 and MICU2 form a disulfide-linked heterodimer that stimulate and inhibit MCU activity, depending on the concentration of calcium (PubMed:24560927). MICU2 acts as a gatekeeper of MCU that senses calcium level via its EF-hand domains: prevents channel opening at resting Ca(2+), avoiding energy dissipation and cell-death triggering (PubMed:24560927).<ref>PMID:23409044</ref> <ref>PMID:24560927</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Grabarek, Z]]
+[[Category: Kamer, K J]]
+[[Category: Calcium]]
+[[Category: Channel]]
+[[Category: Ef hand]]
+[[Category: Metal binding protein]]
+[[Category: Mitochondria]]
+[[Category: Uniporter]]