6hd1: Difference between revisions
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==human STEAP4 bound to NADPH, FAD and heme.== | |||
<StructureSection load='6hd1' size='340' side='right' caption='[[6hd1]], [[Resolution|resolution]] 3.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6hd1]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HD1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HD1 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=44E:(2R)-3-(PHOSPHONOOXY)PROPANE-1,2-DIYL+DIHEXANOATE'>44E</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr> | |||
[[Category: | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6hcy|6hcy]]</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hd1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hd1 OCA], [http://pdbe.org/6hd1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hd1 RCSB], [http://www.ebi.ac.uk/pdbsum/6hd1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hd1 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/STEA4_HUMAN STEA4_HUMAN]] Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+) (By similarity). Uses NADP(+) as acceptor (By similarity). Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By similarity). Associated with obesity and insulin-resistance (PubMed:18430367, PubMed:18381574). Involved in inflammatory arthritis, through the regulation of inflammatory cytokines (PubMed:19660107). Inhibits anchorage-independent cell proliferation (PubMed:19787193).<ref>PMID:18381574</ref> <ref>PMID:18430367</ref> <ref>PMID:19660107</ref> <ref>PMID:19787193</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Bezouwen, L S.van]] | |||
[[Category: Forster, F]] | |||
[[Category: Gros, P]] | |||
[[Category: Mattevi, A]] | |||
[[Category: Oosterheert, W]] | |||
[[Category: Rodenburg, R N.P]] | |||
[[Category: Cofactor-binding]] | |||
[[Category: Electron transfer]] | |||
[[Category: Enzyme]] | |||
[[Category: Membrane protein]] | |||
[[Category: Metalloreductase]] | |||
Revision as of 05:59, 24 October 2018
human STEAP4 bound to NADPH, FAD and heme.
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