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==The structure of the NK1 fragment of HGF/SF complexed with HEPES==
==The structure of the NK1 fragment of HGF/SF complexed with HEPES==
<StructureSection load='5coe' size='340' side='right' caption='[[5coe]], [[Resolution|resolution]] 2.18&Aring;' scene=''>
<StructureSection load='5coe' size='340' side='right'caption='[[5coe]], [[Resolution|resolution]] 2.18&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5coe]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5COE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5COE FirstGlance]. <br>
<table><tr><td colspan='2'>[[5coe]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5COE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5COE FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1nk1|1nk1]], [[1bht|1bht]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5coe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5coe OCA], [https://pdbe.org/5coe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5coe RCSB], [https://www.ebi.ac.uk/pdbsum/5coe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5coe ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HGF, HPTA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5coe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5coe OCA], [http://pdbe.org/5coe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5coe RCSB], [http://www.ebi.ac.uk/pdbsum/5coe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5coe ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/HGF_HUMAN HGF_HUMAN]] Defects in HGF are the cause of deafness autosomal recessive type 39 (DFNB39) [MIM:[http://omim.org/entry/608265 608265]]. A form of profound prelingual sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.<ref>PMID:19576567</ref>
[https://www.uniprot.org/uniprot/HGF_HUMAN HGF_HUMAN] Defects in HGF are the cause of deafness autosomal recessive type 39 (DFNB39) [MIM:[https://omim.org/entry/608265 608265]. A form of profound prelingual sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.<ref>PMID:19576567</ref>  
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/HGF_HUMAN HGF_HUMAN]] Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.<ref>PMID:15167892</ref> <ref>PMID:20624990</ref>
[https://www.uniprot.org/uniprot/HGF_HUMAN HGF_HUMAN] Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.<ref>PMID:15167892</ref> <ref>PMID:20624990</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Ascher, D B]]
[[Category: Large Structures]]
[[Category: Blundell, T L]]
[[Category: Ascher DB]]
[[Category: Chirgadze, D Y]]
[[Category: Blundell TL]]
[[Category: Fragai, M]]
[[Category: Chirgadze DY]]
[[Category: Gherardi, E]]
[[Category: Fragai M]]
[[Category: Sigurdardottir, A G]]
[[Category: Gherardi E]]
[[Category: Sobkowicz, A]]
[[Category: Sigurdardottir AG]]
[[Category: Winter, A]]
[[Category: Sobkowicz A]]
[[Category: Cell cycle]]
[[Category: Winter A]]
[[Category: Fragment based discovery]]
[[Category: Growth factor]]
[[Category: Hgf/sf]]
[[Category: Hormone]]
[[Category: Nk1 fragment]]
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