6hhd: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6hhd is ~~ON HOLD~~

==Mouse Prion Protein in complex with Nanobody 484==

~~Authors~~: ~~Soror~~, S., ~~Abskharon~~, R., ~~Wohlkonig~~, A.

== Structural highlights ==

<table><tr><td colspan='2'>[[6hhd]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HHD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HHD FirstGlance]. <br>

~~Description~~: ~~Mouse Prion Protein~~ in ~~complex~~ with ~~Nanobody 484~~

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

[[~~Category~~: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hhd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hhd OCA], [http://pdbe.org/6hhd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hhd RCSB], [http://www.ebi.ac.uk/pdbsum/6hhd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hhd ProSAT]</span></td></tr>

[[Category: ~~Wohlkonig, A~~]]

</table>

== Disease ==

[[http://www.uniprot.org/uniprot/PRIO_MOUSE PRIO_MOUSE]] Note=Found in high quantity in the brain of humans and animals infected with degenerative neurological diseases such as kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc.

== Function ==

[[http://www.uniprot.org/uniprot/PRIO_MOUSE PRIO_MOUSE]] May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains.<ref>PMID:12732622</ref> <ref>PMID:16492732</ref> <ref>PMID:19242475</ref> <ref>PMID:19568430</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Abskharon, R]]

[[Category: Soror, S]]

[[Category: Wohlkonig, A]]

[[Category: Aggregation]]

[[Category: B-sheet]]

[[Category: Nanobody]]

[[Category: Prion]]

[[Category: Protein binding]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6hhd is ON HOLD
+==Mouse Prion Protein in complex with Nanobody 484==
+<StructureSection load='6hhd' size='340' side='right'caption='[[6hhd]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
-Authors: Soror, S., Abskharon, R., Wohlkonig, A.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6hhd]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HHD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HHD FirstGlance]. <br>
-Description: Mouse Prion Protein in complex with Nanobody 484
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hhd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hhd OCA], [http://pdbe.org/6hhd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hhd RCSB], [http://www.ebi.ac.uk/pdbsum/6hhd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hhd ProSAT]</span></td></tr>
-[[Category: Wohlkonig, A]]
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/PRIO_MOUSE PRIO_MOUSE]] Note=Found in high quantity in the brain of humans and animals infected with degenerative neurological diseases such as kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc.
+== Function ==
+[[http://www.uniprot.org/uniprot/PRIO_MOUSE PRIO_MOUSE]] May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains.<ref>PMID:12732622</ref> <ref>PMID:16492732</ref> <ref>PMID:19242475</ref> <ref>PMID:19568430</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Abskharon, R]]
 [[Category: Soror, S]]
+[[Category: Wohlkonig, A]]
+[[Category: Aggregation]]
+[[Category: B-sheet]]
+[[Category: Nanobody]]
+[[Category: Prion]]
+[[Category: Protein binding]]