6hi4: Difference between revisions
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The | ==The ATAD2 bromodomain in complex with compound 7== | ||
<StructureSection load='6hi4' size='340' side='right' caption='[[6hi4]], [[Resolution|resolution]] 1.69Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6hi4]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HI4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HI4 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=G5W:(2~{R})-2-azanyl-~{N}-[4-ethanoyl-5-(3-methoxyphenyl)-1,3-thiazol-2-yl]propanamide'>G5W</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
[[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hi4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hi4 OCA], [http://pdbe.org/6hi4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hi4 RCSB], [http://www.ebi.ac.uk/pdbsum/6hi4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hi4 ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/ATAD2_HUMAN ATAD2_HUMAN]] May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.<ref>PMID:17998543</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Caflisch, A]] | [[Category: Caflisch, A]] | ||
[[Category: Sledz, P]] | [[Category: Sledz, P]] | ||
[[Category: Atad2]] | |||
[[Category: Bromodomain]] | |||
[[Category: Complex]] | |||
[[Category: Cytosolic protein]] | |||
[[Category: Inhibitor]] | |||
Revision as of 06:44, 21 February 2019
The ATAD2 bromodomain in complex with compound 7
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