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==Crystal structure of a DnaN sliding clamp DNA polymerase III subunit beta from Rickettsia bellii RML369-C==
==Crystal structure of a DnaN sliding clamp DNA polymerase III subunit beta from Rickettsia bellii RML369-C==
<StructureSection load='6man' size='340' side='right' caption='[[6man]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
<StructureSection load='6man' size='340' side='right'caption='[[6man]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6man]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MAN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MAN FirstGlance]. <br>
<table><tr><td colspan='2'>[[6man]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rickettsia_bellii_RML369-C Rickettsia bellii RML369-C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MAN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MAN FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6man FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6man OCA], [http://pdbe.org/6man PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6man RCSB], [http://www.ebi.ac.uk/pdbsum/6man PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6man ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6man FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6man OCA], [https://pdbe.org/6man PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6man RCSB], [https://www.ebi.ac.uk/pdbsum/6man PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6man ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/DPO3B_RICBR DPO3B_RICBR]] Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.[UniProtKB:P0A988]  
[https://www.uniprot.org/uniprot/DPO3B_RICBR DPO3B_RICBR] Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.[UniProtKB:P0A988]
 
==See Also==
*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Rickettsia bellii RML369-C]]
[[Category: Structural genomic]]
[[Category: Structural genomic]]
[[Category: Antibiotic]]
[[Category: Dnan]]
[[Category: Griselimycin]]
[[Category: National institute of allergy and infectious disease]]
[[Category: Niaid]]
[[Category: Polymerase]]
[[Category: Sliding clamp]]
[[Category: Ssgcid]]
[[Category: Structural genomoic]]
[[Category: Transcription]]
Retrieved from "https://proteopedia.org/6man"