6m8s: Difference between revisions
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==Crystal structure of the KCTD12 H1 domain in complex with Gbeta1gamma2 subunits== | |||
<StructureSection load='6m8s' size='340' side='right' caption='[[6m8s]], [[Resolution|resolution]] 3.71Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6m8s]] is a 15 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6M8S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6M8S FirstGlance]. <br> | |||
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6m8r|6m8r]]</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6m8s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6m8s OCA], [http://pdbe.org/6m8s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6m8s RCSB], [http://www.ebi.ac.uk/pdbsum/6m8s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6m8s ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/GBB1_HUMAN GBB1_HUMAN]] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.<ref>PMID:18611381</ref> [[http://www.uniprot.org/uniprot/KCD12_HUMAN KCD12_HUMAN]] Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity). [[http://www.uniprot.org/uniprot/GBG2_HUMAN GBG2_HUMAN]] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity). | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Kruse, A C]] | |||
[[Category: Zheng, S]] | |||
[[Category: Beta-propeller]] | |||
[[Category: Gabab desensitization]] | |||
[[Category: Homopentamer]] | |||
[[Category: Signaling protein]] | |||
Revision as of 15:28, 27 February 2019
Crystal structure of the KCTD12 H1 domain in complex with Gbeta1gamma2 subunits
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