|
|
| Line 34: |
Line 34: |
| **[[4tpg]], [[4tpj]] – SoSymp + tripeptide<BR /> | | **[[4tpg]], [[4tpj]] – SoSymp + tripeptide<BR /> |
|
| |
|
| *Sodium/bile acid symporter | | *Bile acid/Na+ symporter |
|
| |
|
| **[[4n7w]] – YfSymp – ''Yersinia frederiksenii''<BR /> | | **[[4n7w]] – YfSymp – ''Yersinia frederiksenii''<BR /> |
| Line 51: |
Line 51: |
| **[[1pv7]], [[4oaa]] – EcSymp (mutant) + thiodigalactoside<BR /> | | **[[1pv7]], [[4oaa]] – EcSymp (mutant) + thiodigalactoside<BR /> |
|
| |
|
| *Sodium/glucose symporter | | *Glucose/Na+ symporter |
|
| |
|
| **[[2xq2]] – VpSymp (mutant) – ''Vibrio parahaemolyticus''<BR /> | | **[[2xq2]] – VpSymp (mutant) – ''Vibrio parahaemolyticus''<BR /> |
| Line 57: |
Line 57: |
| **[[4m64]] – Symp (mutant) - ''Salmonella typhimurium''<BR /> | | **[[4m64]] – Symp (mutant) - ''Salmonella typhimurium''<BR /> |
|
| |
|
| *Sodium/citrate symporter | | *Citrate/Na+ symporter |
|
| |
|
| **[[5a1s]] – Symp + citrate – ''Salmonella enterica''<BR /> | | **[[5a1s]] – Symp + citrate + Na – ''Salmonella enterica''<BR /> |
| **[[5x9r]], [[5xas]], [[5xat]] – KpSymp + citrate – ''Klebsiella pneumoniae''<BR /> | | **[[5x9r]], [[5xas]], [[5xat]] – KpSymp + citrate + Na – ''Klebsiella pneumoniae''<BR /> |
| **[[4bpq]], [[5xar]] – KpSymp <BR /> | | **[[4bpq]], [[5xar]] – KpSymp <BR /> |
|
| |
|
| *Sodium/neurotransmitter symporter LeuT | | *Neurotransmitter/leucine symporter LeuT |
|
| |
|
| **[[3qs4]], [[3qs5]], [[3qs6]] – AaSymp (mutant) + tryptophan – ''Aquifex aeolicus''<BR /> | | **[[5jaf]], [[5jae]] – AaSymp - ''Aquifex aeolicus''<BR /> |
| **[[3f4i]] – AaSymp + Na <BR /> | | **[[5jag]] – AaSymp (mutant) <BR /> |
| | **[[3gjd]] – AaSymp + Na <BR /> |
| **[[3f48]] – AaSymp + alaine + Na<BR /> | | **[[3f48]] – AaSymp + alaine + Na<BR /> |
| | **[[3tu0]] – AaSymp (mutant) + alanine + Na <BR /> |
| **[[3f4j]] – AaSymp + glycine + Na<BR /> | | **[[3f4j]] – AaSymp + glycine + Na<BR /> |
| **[[2a65]] – AaSymp + leucine <BR /> | | **[[2a65]], [[3f3e]], [[3usg]], [[3usi]], [[3usj]], [[3usk]] – AaSymp + leucine + Na<BR /> |
| **[[2qb4]] – AaSymp + leucine + desipramine<BR /> | | **[[3mpn]], [[3mpq]], [[3gjc]], [[4hmk]], [[4hod]], [[4fxz]] – AaSymp (mutant) + leucine + Na<BR /> |
| **[[2qei]] – AaSymp + alaine + clomipramine<BR /> | | **[[3f3a]] – AaSymp + tryptophan + Na <BR /> |
| | **[[3qs4]], [[3qs5]], [[3qs6]] – AaSymp (mutant) + tryptophan + Na <BR /> |
| | **[[3f3c]] – AaSymp + phenylalanine + Na <BR /> |
| | **[[3f3d]], [[3f4i]], [[3usl]], [[3usm]], [[3uso]] – AaSymp + methionine derivative + Na <BR /> |
| | **[[4fy0]] – AaSymp (mutant) + methionine + Na <BR /> |
| | **[[2qei]] – AaSymp + alaine + clomipramine + Na<BR /> |
| **[[3gwu]] – AaSymp + sertraline + Na<BR /> | | **[[3gwu]] – AaSymp + sertraline + Na<BR /> |
| **[[3gwv]], [[3gww]] – AaSymp + fluoxetine + Na<BR /> | | **[[3gwv]], [[3gww]], [[2qb4]], [[2q6h]], [[2q72]], [[2qju]] – AaSymp + drug + Na<BR /> |
| | **[[4mm4]] – AaSymp (mutant) + drug + Na<BR /> |
| | **[[3usp]] – AaSymp + glucoside derivative + Na <BR /> |
| | **[[3tt1]], [[3tt3]] – AaSymp (mutant) + antibody + Na <BR /> |
|
| |
|
| *Divalent ion/sodium symporter | | *Divalent ion/Na+ symporter |
|
| |
|
| **[[5ul7]], [[5ul9]], [[5uld]], [[5ule]], [[4f35]] – Symp + Na – ''Vibrio cholerae''<BR /> | | **[[5ul7]], [[5ul9]], [[5uld]], [[5ule]], [[4f35]] – Symp + Na – ''Vibrio cholerae''<BR /> |
| Function
Symporter (Symp) is a co-transporter membrane protein which transports two or more different molecules across the plasma membrane in the same direction[1].
Disease
Mutations in sodium/iodide symporter cause iodide transport defects[2].
Structural highlights
Dipeptide:H symporter binds the dipeptide between its N- and C-terminal bundles[3].
- ↑ Dohan O, De la Vieja A, Paroder V, Riedel C, Artani M, Reed M, Ginter CS, Carrasco N. The sodium/iodide Symporter (NIS): characterization, regulation, and medical significance. Endocr Rev. 2003 Feb;24(1):48-77. PMID:12588808 doi:https://dx.doi.org/10.1210/er.2001-0029
- ↑ Pohlenz J, Refetoff S. Mutations in the sodium/iodide symporter (NIS) gene as a cause for iodide transport defects and congenital hypothyroidism. Biochimie. 1999 May;81(5):469-76. PMID:10403177
- ↑ Lyons JA, Parker JL, Solcan N, Brinth A, Li D, Shah ST, Caffrey M, Newstead S. Structural basis for polyspecificity in the POT family of proton-coupled oligopeptide transporters. EMBO Rep. 2014 Jun 10. pii: e201338403. PMID:24916388 doi:https://dx.doi.org/10.15252/embr.201338403
|
3D Structures of symporter
Updated on 24-September-2018
{"openlevels":0}
- D-xylose/H+ symporter
- 4ja4, 4qiq – EcSymp – Escherichia coli
- 4ja3 – EcSymp (mutant)
- 4gby – EcSymp + xylose
- 4gbz, 4gc0 – EcSymp + glucose derivative
- Di-or tripeptide/H+ symporter
- 4ja4, 4xni, 4xnj, 4d2b, 4aps, 5d6k, 5mmt, 5d6k, 5oxo, 5oxp, 5oxq, 6eia, 6fmr, 6fmy – StSymp – Streptococcus thermophilus
- 4d2d, 6ghj – StSymp + tripeptide
- 4d2c, 5d58, 5d59, 5oxk, 5oxl, 5oxm, 5oxn – StSymp + dipeptide
- Oligopeptide/H+ symporter
- Bile acid/Na+ symporter
- 4n7w – YfSymp – Yersinia frederiksenii
- 4n7x – YfSymp (mutant)
- 3zuy – Symp - Neisseria meningitidis
- 3zux – Symp (mutant)
- L-fucose/H+ symporter
- Lactose/H+ symporter
- 1pv6 – EcSymp (mutant)
- 1pv7, 4oaa – EcSymp (mutant) + thiodigalactoside
- Glucose/Na+ symporter
- 2xq2 – VpSymp (mutant) – Vibrio parahaemolyticus
- 3dh4 – VpSymp + galactose
- 4m64 – Symp (mutant) - Salmonella typhimurium
- Citrate/Na+ symporter
- 5a1s – Symp + citrate + Na – Salmonella enterica
- 5x9r, 5xas, 5xat – KpSymp + citrate + Na – Klebsiella pneumoniae
- 4bpq, 5xar – KpSymp
- Neurotransmitter/leucine symporter LeuT
- 5jaf, 5jae – AaSymp - Aquifex aeolicus
- 5jag – AaSymp (mutant)
- 3gjd – AaSymp + Na
- 3f48 – AaSymp + alaine + Na
- 3tu0 – AaSymp (mutant) + alanine + Na
- 3f4j – AaSymp + glycine + Na
- 2a65, 3f3e, 3usg, 3usi, 3usj, 3usk – AaSymp + leucine + Na
- 3mpn, 3mpq, 3gjc, 4hmk, 4hod, 4fxz – AaSymp (mutant) + leucine + Na
- 3f3a – AaSymp + tryptophan + Na
- 3qs4, 3qs5, 3qs6 – AaSymp (mutant) + tryptophan + Na
- 3f3c – AaSymp + phenylalanine + Na
- 3f3d, 3f4i, 3usl, 3usm, 3uso – AaSymp + methionine derivative + Na
- 4fy0 – AaSymp (mutant) + methionine + Na
- 2qei – AaSymp + alaine + clomipramine + Na
- 3gwu – AaSymp + sertraline + Na
- 3gwv, 3gww, 2qb4, 2q6h, 2q72, 2qju – AaSymp + drug + Na
- 4mm4 – AaSymp (mutant) + drug + Na
- 3usp – AaSymp + glucoside derivative + Na
- 3tt1, 3tt3 – AaSymp (mutant) + antibody + Na
- Divalent ion/Na+ symporter
- Purine/H+ symporter
- 5i6c – Symp + xanthine – Aspergillus nidulans
- Glutamate/H+ symporter
- 5dwy, 4ky0 – TkSymp – Thermococcus kodakarensis
- 5e9s – TkSymp + aspartate
- 4oyf – PhSymp - Pyrococcus horikishii
- 2nwl – PhSymp (mutant) + aspartate
References
