6al3: Difference between revisions
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==Lys49 PLA2 BPII derived from the venom of Protobothrops flavoviridis.== | |||
<StructureSection load='6al3' size='340' side='right' caption='[[6al3]], [[Resolution|resolution]] 2.57Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6al3]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Protobothrops_flavoviridis Protobothrops flavoviridis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AL3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AL3 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
[[Category: | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6al3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6al3 OCA], [http://pdbe.org/6al3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6al3 RCSB], [http://www.ebi.ac.uk/pdbsum/6al3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6al3 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/PA2B2_PROFL PA2B2_PROFL]] Snake venom phospholipase A2 (PLA2) that shows anticoagulant activities, strong myolytic activity, infiltration of polymorphonuclear cells, and edema in stromal tissues. Induces cell death of Jurkat cells in a concentration dependent manner. Shows a low phospholipase A2 activity. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.<ref>PMID:19463843</ref> <ref>PMID:2341374</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Protobothrops flavoviridis]] | |||
[[Category: Kamata, S]] | |||
[[Category: Matsui, T]] | |||
[[Category: Oda-Ueda, N]] | |||
[[Category: Ogawa, T]] | |||
[[Category: Suzuki, A]] | |||
[[Category: Tanaka, Y]] | |||
[[Category: Nake venom]] | |||
[[Category: Phospholipase a2]] | |||
[[Category: Toxic component]] | |||
[[Category: Toxin]] | |||
