6hkq: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6hkq is ~~ON HOLD until Paper Publication~~

==Human GPX4 in complex with covalent Inhibitor ML162 (S enantiomer)==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[6hkq]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HKQ OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HKQ FirstGlance].

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=G9N:(2~{S})-2-[2-chloranylethanoyl-(3-chloranyl-4-methoxy-phenyl)amino]-~{N}-(2-phenylethyl)-2-thiophen-2-yl-ethanamide'>G9N</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[6hn3|6hn3]]</td></tr>

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Phospholipid-hydroperoxide_glutathione_peroxidase Phospholipid-hydroperoxide glutathione peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.12 1.11.1.12] </td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hkq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hkq OCA], [http://pdbe.org/6hkq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hkq RCSB], [http://www.ebi.ac.uk/pdbsum/6hkq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hkq ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/GPX4_HUMAN GPX4_HUMAN]] Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage (By similarity).

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Phospholipid-hydroperoxide glutathione peroxidase]]

[[Category: Badock, V]]

[[Category: Eaton, J K]]

[[Category: Gradl, S]]

[[Category: Hillig, R C]]

[[Category: Hilpmann, A]]

[[Category: Hoffmann, L]]

[[Category: Moosmayer, D]]

[[Category: Schnirch, L]]

[[Category: Anti-oxidatve defense system]]

[[Category: Covalent inhibitor]]

[[Category: Oxidoreductase]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6hkq is ON HOLD  until Paper Publication
+==Human GPX4 in complex with covalent Inhibitor ML162 (S enantiomer)==
+<StructureSection load='6hkq' size='340' side='right'caption='[[6hkq]], [[Resolution|resolution]] 1.54&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6hkq]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HKQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HKQ FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=G9N:(2~{S})-2-[2-chloranylethanoyl-(3-chloranyl-4-methoxy-phenyl)amino]-~{N}-(2-phenylethyl)-2-thiophen-2-yl-ethanamide'>G9N</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6hn3|6hn3]]</td></tr>
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipid-hydroperoxide_glutathione_peroxidase Phospholipid-hydroperoxide glutathione peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.12 1.11.1.12] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hkq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hkq OCA], [http://pdbe.org/6hkq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hkq RCSB], [http://www.ebi.ac.uk/pdbsum/6hkq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hkq ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/GPX4_HUMAN GPX4_HUMAN]] Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage (By similarity).
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Phospholipid-hydroperoxide glutathione peroxidase]]
+[[Category: Badock, V]]
+[[Category: Eaton, J K]]
+[[Category: Gradl, S]]
+[[Category: Hillig, R C]]
+[[Category: Hilpmann, A]]
+[[Category: Hoffmann, L]]
+[[Category: Moosmayer, D]]
+[[Category: Schnirch, L]]
+[[Category: Anti-oxidatve defense system]]
+[[Category: Covalent inhibitor]]
+[[Category: Oxidoreductase]]