6mbc: Difference between revisions

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'''Unreleased structure'''


The entry 6mbc is ON HOLD  until Paper Publication
==Human Bfl-1 in complex with the designed peptide dF4==
<StructureSection load='6mbc' size='340' side='right'  caption='[[6mbc]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6mbc]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MBC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MBC FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mbc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mbc OCA], [http://pdbe.org/6mbc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mbc RCSB], [http://www.ebi.ac.uk/pdbsum/6mbc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mbc ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/B2LA1_HUMAN B2LA1_HUMAN]] Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection (By similarity).
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Understanding the relationship between protein sequence and structure well enough to design new proteins with desired functions is a longstanding goal in protein science. Here, we show that recurring tertiary structural motifs (TERMs) in the PDB provide rich information for protein-peptide interaction prediction and design. TERM statistics can be used to predict peptide binding energies for Bcl-2 family proteins as accurately as widely used structure-based tools. Furthermore, design using TERM energies (dTERMen) rapidly and reliably generates high-affinity peptide binders of anti-apoptotic proteins Bfl-1 and Mcl-1 with just 15%-38% sequence identity to any known native Bcl-2 family protein ligand. High-resolution structures of four designed peptides bound to their targets provide opportunities to analyze the strengths and limitations of the computational design method. Our results support dTERMen as a powerful approach that can complement existing tools for protein engineering.


Authors: Jenson, J.M., Keating, A.E.
Tertiary Structural Motif Sequence Statistics Enable Facile Prediction and Design of Peptides that Bind Anti-apoptotic Bfl-1 and Mcl-1.,Frappier V, Jenson JM, Zhou J, Grigoryan G, Keating AE Structure. 2019 Feb 12. pii: S0969-2126(19)30008-5. doi:, 10.1016/j.str.2019.01.008. PMID:30773399<ref>PMID:30773399</ref>


Description: Human Bfl-1 in complex with the designed peptide dF4
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
[[Category: Jenson, J.M]]
<div class="pdbe-citations 6mbc" style="background-color:#fffaf0;"></div>
[[Category: Keating, A.E]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Jenson, J M]]
[[Category: Keating, A E]]
[[Category: Anti-apoptotic bcl-2]]
[[Category: Apoptosis]]
[[Category: Design]]
[[Category: Inhibitor]]
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