6mgw: Difference between revisions
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==Structure of mechanically activated ion channel OSCA1.2 in LMNG== | |||
<StructureSection load='6mgw' size='340' side='right' caption='[[6mgw]], [[Resolution|resolution]] 3.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6mgw]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MGW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MGW FirstGlance]. <br> | |||
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6mgv|6mgv]]</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mgw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mgw OCA], [http://pdbe.org/6mgw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mgw RCSB], [http://www.ebi.ac.uk/pdbsum/6mgw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mgw ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/CSC1_ARATH CSC1_ARATH]] Acts as an osmosensitive calcium-permeable cation channel. Specifically conducts cations including Ca(2+), K(+) and Na(+) in vitro. Inactivation or closure of the channel is calcium-dependent.<ref>PMID:24503647</ref> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Mechanically activated ion channels underlie touch, hearing, shear-stress sensing, and response to turgor pressure. OSCA/TMEM63s are a newly-identified family of eukaryotic mechanically activated ion channels opened by membrane tension. The structural underpinnings of OSCA/TMEM63 function are not explored. Here, we elucidate high resolution cryo-electron microscopy structures of OSCA1.2, revealing a dimeric architecture containing eleven transmembrane helices per subunit and surprising topological similarities to TMEM16 proteins. We locate the ion permeation pathway within each subunit by demonstrating that a conserved acidic residue is a determinant of channel conductance. Molecular dynamics simulations reveal membrane interactions, suggesting the role of lipids in OSCA1.2 gating. These results lay a foundation to decipher how the structural organization of OSCA/TMEM63 is suited for their roles as MA ion channels. | |||
Cryo-EM structure of the mechanically activated ion channel OSCA1.2.,Jojoa Cruz S, Saotome K, Murthy SE, Tsui CCA, Sansom MS, Patapoutian A, Ward AB Elife. 2018 Nov 1;7. pii: 41845. doi: 10.7554/eLife.41845. PMID:30382939<ref>PMID:30382939</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 6mgw" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Jojoa-Cruz, S]] | [[Category: Jojoa-Cruz, S]] | ||
[[Category: Patapoutian, A]] | [[Category: Patapoutian, A]] | ||
[[Category: Saotome, K]] | [[Category: Saotome, K]] | ||
[[Category: Ward, A B]] | |||
[[Category: Mechanically activated ion channel]] | |||
[[Category: Membrane protein]] | |||
Revision as of 08:23, 14 November 2018
Structure of mechanically activated ion channel OSCA1.2 in LMNG
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