6hqa: Difference between revisions
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==Molecular structure of promoter-bound yeast TFIID== | |||
<SX load='6hqa' size='340' side='right' viewer='molstar' caption='[[6hqa]], [[Resolution|resolution]] 7.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6hqa]] is a 11 chain structure with sequence from [http://en.wikipedia.org/wiki/Kompg Kompg] and [http://en.wikipedia.org/wiki/Komagataella_phaffii_gs115 Komagataella phaffii gs115]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HQA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HQA FirstGlance]. <br> | |||
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hqa OCA], [http://pdbe.org/6hqa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hqa RCSB], [http://www.ebi.ac.uk/pdbsum/6hqa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hqa ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Transcription preinitiation complex assembly on the promoters of protein encoding genes is nucleated in vivo by TFIID composed of the TATA-box Binding Protein (TBP) and 13 TBP-associate factors (Tafs) providing regulatory and chromatin binding functions. Here we present the cryo-electron microscopy structure of promoter-bound yeast TFIID at a resolution better than 5 A, except for a flexible domain. We position the crystal structures of several subunits and, in combination with cross-linking studies, describe the quaternary organization of TFIID. The compact tri lobed architecture is stabilized by a topologically closed Taf5-Taf6 tetramer. We confirm the unique subunit stoichiometry prevailing in TFIID and uncover a hexameric arrangement of Tafs containing a histone fold domain in the Twin lobe. | |||
Molecular structure of promoter-bound yeast TFIID.,Kolesnikova O, Ben-Shem A, Luo J, Ranish J, Schultz P, Papai G Nat Commun. 2018 Nov 7;9(1):4666. doi: 10.1038/s41467-018-07096-y. PMID:30405110<ref>PMID:30405110</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: | <div class="pdbe-citations 6hqa" style="background-color:#fffaf0;"></div> | ||
== References == | |||
<references/> | |||
__TOC__ | |||
</SX> | |||
[[Category: Komagataella phaffii gs115]] | |||
[[Category: Kompg]] | |||
[[Category: Large Structures]] | |||
[[Category: Ben-Shem, A]] | [[Category: Ben-Shem, A]] | ||
[[Category: Kolesnikova, O]] | [[Category: Kolesnikova, O]] | ||
[[Category: Luo, J]] | |||
[[Category: Papai, G]] | [[Category: Papai, G]] | ||
[[Category: | [[Category: Ranish, J]] | ||
[[Category: Schultz, P]] | [[Category: Schultz, P]] | ||
[[Category: Complex]] | |||
[[Category: Transcription]] | |||
[[Category: Transcription initiation]] | |||
Revision as of 21:54, 6 March 2020
Molecular structure of promoter-bound yeast TFIID
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