6mks: Difference between revisions
From Proteopedia
Jump to navigationJump to search
m Protected "6mks" [edit=sysop:move=sysop] |
No edit summary |
||
| Line 1: | Line 1: | ||
==Cryo-EM structure of NLRC4-CARD filament== | |||
<StructureSection load='6mks' size='340' side='right' caption='[[6mks]], [[Resolution|resolution]] 3.40Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6mks]] is a 31 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MKS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MKS FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mks FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mks OCA], [http://pdbe.org/6mks PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mks RCSB], [http://www.ebi.ac.uk/pdbsum/6mks PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mks ProSAT]</span></td></tr> | |||
[[Category: | </table> | ||
[[Category: | == Disease == | ||
[[http://www.uniprot.org/uniprot/NLRC4_HUMAN NLRC4_HUMAN]] The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/NLRC4_HUMAN NLRC4_HUMAN]] Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis (PubMed:15107016). The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria (By similarity).[UniProtKB:Q3UP24]<ref>PMID:15107016</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Egelman, E H]] | |||
[[Category: Matyszewski, M]] | |||
[[Category: Sohn, J]] | [[Category: Sohn, J]] | ||
[[Category: Zheng, W]] | [[Category: Zheng, W]] | ||
[[Category: Helical assembly]] | |||
[[Category: Inflammasome]] | |||
[[Category: Nlrc4]] | |||
[[Category: Protein fibril]] | |||
Revision as of 12:25, 7 November 2018
Cryo-EM structure of NLRC4-CARD filament
| ||||||||||||
