6mlc: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6mlc is ~~ON HOLD~~

==PHD6 domain of MLL3 in complex with histone H4==

~~Authors~~: ~~Dong~~, A., ~~Liu~~, Y., ~~Qin~~, S., ~~Lei, M~~., ~~Bountra~~, C., Arrowsmith, C.H., Edwards, A.M~~., Min, J., Structural Genomics Consortium (SGC)~~

== Structural highlights ==

<table><tr><td colspan='2'>[[6mlc]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MLC OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MLC FirstGlance].

~~Description~~: ~~PHD6 domain of MLL3 in complex with histone H4~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mlc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mlc OCA], [http://pdbe.org/6mlc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mlc RCSB], [http://www.ebi.ac.uk/pdbsum/6mlc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mlc ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/KMT2C_HUMAN KMT2C_HUMAN]] Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Central component of the MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. KMT2C/MLL3 may be a catalytic subunit of this complex. May be involved in leukemogenesis and developmental disorder.<ref>PMID:17500065</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Histone-lysine N-methyltransferase]]

[[Category: Arrowsmith, C H]]

[[Category: Bountra, C]]

[[Category: Dong, A]]

[[Category: Edwards, A M]]

[[Category: Lei, M]]

[[Category: Liu, Y]]

[[Category: Min, J]]

~~[[Category: Edwards, A.M]]~~

~~[[Category: Arrowsmith, C.H]]~~

[[Category: Qin, S]]

[[Category: ~~Dong, A~~]]

[[Category: Structural genomic]]

[[Category: ~~Structural Genomics Consortium (Sgc)~~]]

[[Category: Mll3]]

[[Category: ~~Liu, Y~~]]

[[Category: Phd6]]

[[Category: ~~Lei, M~~]]

[[Category: Sgc]]

[[Category: ~~Bountra, C~~]]

[[Category: Transferase]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6mlc is ON HOLD
+==PHD6 domain of MLL3 in complex with histone H4==
+<StructureSection load='6mlc' size='340' side='right' caption='[[6mlc]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
-Authors: Dong, A., Liu, Y., Qin, S., Lei, M., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6mlc]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MLC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MLC FirstGlance]. <br>
-Description: PHD6 domain of MLL3 in complex with histone H4
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mlc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mlc OCA], [http://pdbe.org/6mlc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mlc RCSB], [http://www.ebi.ac.uk/pdbsum/6mlc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mlc ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/KMT2C_HUMAN KMT2C_HUMAN]] Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Central component of the MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. KMT2C/MLL3 may be a catalytic subunit of this complex. May be involved in leukemogenesis and developmental disorder.<ref>PMID:17500065</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Histone-lysine N-methyltransferase]]
+[[Category: Arrowsmith, C H]]
+[[Category: Bountra, C]]
+[[Category: Dong, A]]
+[[Category: Edwards, A M]]
+[[Category: Lei, M]]
+[[Category: Liu, Y]]
 [[Category: Min, J]]
-[[Category: Edwards, A.M]]
-[[Category: Arrowsmith, C.H]]
 [[Category: Qin, S]]
-[[Category: Dong, A]]
+[[Category: Structural genomic]]
-[[Category: Structural Genomics Consortium (Sgc)]]
+[[Category: Mll3]]
-[[Category: Liu, Y]]
+[[Category: Phd6]]
-[[Category: Lei, M]]
+[[Category: Sgc]]
-[[Category: Bountra, C]]
+[[Category: Transferase]]