Virus protease: Difference between revisions
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'''Virus proteases''' include HIV protease, XMRV protease, retropepsin. | '''Virus proteases''' include HIV protease, XMRV protease, retropepsin. | ||
HIV Protease (HIV-PR) and xenotropic murine leukemia virus protease (XMRV-PR) cleave polyproteins to produce the mature proteins of the virus. Both are aspartyl proteases. The inhibition of HIV-PR results in an uninfectious HIV virion. HIV-1 is found globally while HIV-2, which has lower virulence, is found in West Africa. | HIV Protease (HIV-PR) and xenotropic murine leukemia virus protease (XMRV-PR) cleave polyproteins to produce the mature proteins of the virus<ref>PMID:12475203</ref>. Both are aspartyl proteases. The inhibition of HIV-PR results in an uninfectious HIV virion. HIV-1 is found globally while HIV-2, which has lower virulence, is found in West Africa. | ||
*<scene name='44/443708/Cv/3'>HIV-1 protease dimer complex with inhibitor tert-butylcarbonate </scene>. | *<scene name='44/443708/Cv/3'>HIV-1 protease dimer complex with inhibitor tert-butylcarbonate </scene>. | ||
*<scene name='44/443708/Cv/5'>Inhibitor BMS-182193 binding site</scene>. | *<scene name='44/443708/Cv/5'>Inhibitor BMS-182193 binding site</scene>. | ||
