Virus protease: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
Michal Harel (talk | contribs)
32,849 edits
No edit summary
Michal Harel (talk | contribs)
32,849 edits
No edit summary
Line 1: Line 1:
<StructureSection load='' size='350' side='right' caption='Structure of human rhinovirus 3C protease complex with inhibitor (PDB entry [[1cqq]])' scene='55/554890/Cv/1'>
<StructureSection load='' size='350' side='right' caption='Structure of human rhinovirus 3C protease complex with inhibitor (PDB entry [[1cqq]])' scene='55/554890/Cv/1'>
__TOC__
__TOC__
== Function ==
== Function ==
      
      
'''3C protease''' (3CP) is a virus cysteine protease which has essential role in viral replication.  3CP cleaves the precursor viral polyprotein to produce functional proteins and enzymes.<ref>PMID:17305557</ref>  For more details on Foot and Mouth Disease virus 3C protease see [[FMDV 3C]].
'''Virus protease''' or '''3C protease''' are virus cysteine proteases which have essential role in viral replication.  The protease cleaves the precursor viral polyprotein to produce functional proteins and enzymes.<ref>PMID:17305557</ref>  F


== Disease ==
== Disease ==


3CP is an attractive target for therapeutic agents for treatment of diseases caused by the common cold virus.  Coxsakievirus causes the human diseases myocarditis and pericarditis.
Virus proteases are attractive target for therapeutic agents for treatment of diseases caused by the common cold virus.  Coxsakievirus causes the human diseases myocarditis and pericarditis.


== Structural highlights ==
== Structural highlights ==


3CP - a Cys protease fold is similar to that of trypsin-like serine proteases.  The <scene name='55/554890/Cv/6'>active site triad contains Cys147, His40 and Glu71</scene> (PDB entry [[1cqq]]).<ref>PMID:10500114</ref> <scene name='55/554890/Cv/5'>Whole binding site</scene>.
Viral protease - a Cys protease fold is similar to that of trypsin-like serine proteases.  The <scene name='55/554890/Cv/6'>active site triad contains Cys147, His40 and Glu71</scene> (PDB entry [[1cqq]]).<ref>PMID:10500114</ref> <scene name='55/554890/Cv/5'>Whole binding site</scene>.


See also<br />
See also<br />
Line 24: Line 23:
*[[Molecular Playground/Dengue Virus Protease]]<br />
*[[Molecular Playground/Dengue Virus Protease]]<br />
*[[Viability of a drug-resistant HIV-1 protease mutant]]<br />
*[[Viability of a drug-resistant HIV-1 protease mutant]]<br />
*[[Molecular Playground/Dengue Virus Protease]]
*[[Molecular Playground/Dengue Virus Protease]]<br />
*[[FMDV 3C]] for Foot-and-Mouth virus protease
</StructureSection>
</StructureSection>


Line 75: Line 75:
*'''Hepatitis A virus protease'''
*'''Hepatitis A virus protease'''


**[[2h9h]], [[2hal]] – HAVP residues 1520-1731 (mutant) + polypeptide inhibitor
**[[1hav]] – HAVP (mutant) – hepatitis A virus  <br />
**[[2h9h]], [[2hal]] – HAVP residues 1520-1731 (mutant) + polypeptide inhibitor<br />
**[[2h6m]] – HAVP + peptide inhibitor  <br />
**[[1qa7]], [[3r0f]] – HAVP (mutant) + inhibitor  <br />


*'''Hepatitis C virus protease'''
*'''Hepatitis C virus protease'''
Line 108: Line 111:
*'''Foot-and-Mouth Disease virus protease'''
*'''Foot-and-Mouth Disease virus protease'''


**[[2bhg]] – FMDV residues 1650-1857 (mutant) – Foot-and-mouth disease virus  
**[[2bhg]] – FMDV residues 1650-1857 (mutant) – Foot-and-mouth disease virus <br />
**[[2jqf]], [[2j92]], [[5hm2]] – FMDV (mutant) <br />
**[[2wv4]], [[2wv5]] – FMDV (mutant) + peptide <br />


*'''Infectious Bronchitis virus protease'''
*'''Infectious Bronchitis virus protease'''


**[[2q6d]] – IBV – infectious bronchitis virus <br />
**[[2q6d]], [[4x2z]] – IBV – infectious bronchitis virus <br />
**[[2q6f]] – IBV + inhibitor
**[[2q6f]] – IBV + inhibitor


*'''Yellowtail ascites virus protease'''
*'''Yellowtail ascites virus protease'''


**[[4izj]], [[4izk]] – YAV Vp4 (mutant) – yellowtail ascites virus
**[[4cx8]], [[4b07]], [[4b0t]] – YAV – yellowtail ascites virus<br />
**[[4b08]] – YAV + inhibitor<br />
**[[4izj]], [[4izk]] – YAV Vp4 (mutant)  


*'''Pseudorabies virus protease'''
*'''Pseudorabies virus protease'''


**[[4cx8]] – YAV – pseudorabies virus<br />
**[[4cx8]] – YAV – pseudorabies virus<br />
*'''Coxsakievirus protease'''
**[[2vb0]], [[2zty]], [[2ztz]], [[3zyd]], [[3sj8]] – CSVP <br />
**[[2zu1]], [[3zye]], [[3zz3]], [[3zz4]] – CSVP (mutant)  <br />
**[[2ztx]] – CSVP + Zn-H2S  <br />
**[[2zu3]], [[3zz5]], [[3zz6]], [[3zz7]], [[3zz8]], [[3zz9]], [[3zza]], [[3zzb]], [[3sji]] – CSVP + inhibitor  <br />
**[[3zzc]], [[3zzd]] – CSVP (mutant) + inhibitor  <br />
**[[3sj9]] – CSVP (mutant) + peptide inhibitor  <br />
*'''Human polio virus protease'''
**[[1l1n]] – HPV  <br />
**[[2ijd]] – HPV (mutant)  <br />
*'''Human rhinovirus protease'''
**[[2in2]] – HRVP – human rhinovirus - NMR  <br />
**[[1cqq]], [[2xya]], [[5fx5]], [[5fx6]], [[6ffn]], [[6ffs]] – HRVP + inhibitor  <br />
**[[2b0f]] – HRVP + inhibitor – NMR  <br />
**[[2h6m]] – HRVP + peptide inhibitor  <br />
*'''Human enterovirus protease'''
**[[3osy]] – HEVP 71 – human enterovirus  <br />
**[[3zv8]] – HEVP 68 residues 1549-1731  <br />
**[[3q3x]] – HEVP B (mutant)  <br />
**[[3q3y]] – HEVP B (mutant) + inhibitor  <br />
**[[3ruo]] – HEVP B + inhibitor  <br />
**[[3sjk]] – HEVP 71 (mutant) + peptide inhibitor  <br />
**[[3sjo]], [[5bpe]], [[5hxf]], [[5wq2]] – HEVP 71 + inhibitor  <br />
**[[3qzq]], [[3qzr]] – HEVP 71 (mutant) + inhibitor  <br />
**[[3zv9]], [[3zva]], [[3zvb]], [[3zvc]], [[3zvd]], [[3zve]], [[3zvf]], [[3zvg]] – HEVP 68 + inhibitor  <br />
'''Porcine epidemic diarrhea virus protease'''
**[[5hyo]] – PEDVP – porcine epidemic diarrhea virus  <br />
'''Coronavirus protease'''
**[[4wme]], [[4wmf]] – CVP (mutant)- coronavirus  <br />
'''SARS coronavirus protease'''
**[[3e91]], [[3ea7]], [[3ea8]], [[3ea9]], [[3eaj]] – SCVP (mutant) – SARS coronavirus  <br />
**[[2amd]], [[2amq]], [[2gx4]], [[2z9g]], [[2z9j]], [[2z9k]], [[2z9l]], [[2zu5]], [[4mds]], [[4tww]], [[4twy]] – SCVP + inhibitor  <br />
'''Coronavirus HKU4 protease'''
**[[2ynb]] – CVHP + inhibitor – BAT coronavirus  <br />
'''Echovirus 1 protease'''
**[[5iyt]] – EV1P (mutant) + inhibitor – Echovirus 1  <br />
'''Norovirus protease'''
**[[5e0g]], [[5e0h]], [[5e0j]] – NVP (mutant)+ peptide inhibitor – Norovirus  <br />
**[[3ur9]], [[4imq]], [[4xbb]], [[4xbc]], [[4xbd]], [[5dg6]], [[5dgj]], [[5tg1]], [[5tg2]] – NVP residues 1101-1281 + inhibitor  <br />
'''Norovirus 3C-like protease'''
**[[1wqs]] – NVLP – chiba virus  <br />
'''Gastroentritis virus protease'''
**[[2amp]] – GEVP + inhibitor – gastroenteritis virus  <br />
'''Southampton virus protease'''
**[[2iph]] – SVP + inhibitor – Southampton virus  <br />
'''West Nile virus protease'''
**[[2ggv]] - WNVP (mutant) - West Nile virus<br />
**[[2ijo]] - WNVP (mutant) + BPTI<br />
**[[2yol]], [[5idk]], [[2fp7]] - WNVP + peptide inhibitor<br />
**[[3e90]] - WNVP + inhibitor<br />


}}
}}
Retrieved from "https://proteopedia.org/Virus_protease"