6ea4: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6ea4 is ~~ON HOLD until Paper Publication~~

==ERAP2 bound to Aryl Sulfonamide Uncompetitive Inhibitor==

~~Authors~~: ~~Maben~~, Z., ~~Stern~~, L.J.

== Structural highlights ==

<table><tr><td colspan='2'>[[6ea4]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EA4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EA4 FirstGlance]. <br>

~~Description~~: ~~ERAP2 bound~~ to ~~Aryl Sulfonamide Uncompetitive Inhibitor~~

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=J2G:4-methoxy-3-{[2-(piperidin-1-yl)-4-(trifluoromethyl)phenyl]sulfamoyl}benzoic+acid'>J2G</scene>, <scene name='pdbligand=LYS:LYSINE'>LYS</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ea4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ea4 OCA], [http://pdbe.org/6ea4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ea4 RCSB], [http://www.ebi.ac.uk/pdbsum/6ea4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ea4 ProSAT]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/ERAP2_HUMAN ERAP2_HUMAN]] Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys.<ref>PMID:12799365</ref> <ref>PMID:15908954</ref> <ref>PMID:16286653</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Maben, Z]]

[[Category: Stern, L.J]]

[[Category: Stern, L J]]

[[Category: Aminopeptidase]]

[[Category: Hydrolase]]

[[Category: Hydrolase-inhibitor complex]]

[[Category: Immunity]]

[[Category: Inhibitor]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6ea4 is ON HOLD  until Paper Publication
+==ERAP2 bound to Aryl Sulfonamide Uncompetitive Inhibitor==
+<StructureSection load='6ea4' size='340' side='right'caption='[[6ea4]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
-Authors: Maben, Z., Stern, L.J.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6ea4]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EA4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EA4 FirstGlance]. <br>
-Description: ERAP2 bound to Aryl Sulfonamide Uncompetitive Inhibitor
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=J2G:4-methoxy-3-{[2-(piperidin-1-yl)-4-(trifluoromethyl)phenyl]sulfamoyl}benzoic+acid'>J2G</scene>, <scene name='pdbligand=LYS:LYSINE'>LYS</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ea4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ea4 OCA], [http://pdbe.org/6ea4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ea4 RCSB], [http://www.ebi.ac.uk/pdbsum/6ea4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ea4 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/ERAP2_HUMAN ERAP2_HUMAN]] Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys.<ref>PMID:12799365</ref> <ref>PMID:15908954</ref> <ref>PMID:16286653</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Maben, Z]]
-[[Category: Stern, L.J]]
+[[Category: Stern, L J]]
+[[Category: Aminopeptidase]]
+[[Category: Hydrolase]]
+[[Category: Hydrolase-inhibitor complex]]
+[[Category: Immunity]]
+[[Category: Inhibitor]]