6hsc: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6hsc is ~~ON HOLD~~

==Structure of Human Serum Albumin in complex with Aristolochic Acid at 1.9 A resolution==

~~Authors~~: ~~Pomyalov~~, S., ~~Sidorenko~~, V.S., ~~Grollman, A~~.P., ~~Shoham, G~~.

== Structural highlights ==

<table><tr><td colspan='2'>[[6hsc]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HSC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HSC FirstGlance]. <br>

~~Description~~: ~~Structure~~ of ~~Human~~ Serum ~~Albumin~~ in ~~complex with Aristolochic Acid at 1~~.9 A ~~resolution~~

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOQ:8-methoxy-6-nitro-naphtho[1,2-e][1,3]benzodioxole-5-carboxylic+acid'>GOQ</scene>, <scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hsc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hsc OCA], [http://pdbe.org/6hsc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hsc RCSB], [http://www.ebi.ac.uk/pdbsum/6hsc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hsc ProSAT]</span></td></tr>

</table>

== Disease ==

[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[http://omim.org/entry/103600 103600]]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref> <ref>PMID:7852505</ref> <ref>PMID:9329347</ref> <ref>PMID:9589637</ref>

== Function ==

[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Grollman, A P]]

[[Category: Pomyalov, S]]

[[Category: Shoham, G]]

[[Category: ~~Grollman~~, ~~A.P~~]]

[[Category: Sidorenko, V S]]

[[Category: ~~Pomyalov, S~~]]

[[Category: Aristolochic acid i]]

[[Category: ~~Sidorenko, V.S~~]]

[[Category: Complex]]

[[Category: High resolution]]

[[Category: Human serum albumin]]

[[Category: Transport protein]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6hsc is ON HOLD
+==Structure of Human Serum Albumin in complex with Aristolochic Acid at 1.9 A resolution==
+<StructureSection load='6hsc' size='340' side='right'caption='[[6hsc]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
-Authors: Pomyalov, S., Sidorenko, V.S., Grollman, A.P., Shoham, G.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6hsc]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HSC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HSC FirstGlance]. <br>
-Description: Structure of Human Serum Albumin in complex with Aristolochic Acid at 1.9 A resolution
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOQ:8-methoxy-6-nitro-naphtho[1,2-e][1,3]benzodioxole-5-carboxylic+acid'>GOQ</scene>, <scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hsc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hsc OCA], [http://pdbe.org/6hsc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hsc RCSB], [http://www.ebi.ac.uk/pdbsum/6hsc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hsc ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[http://omim.org/entry/103600 103600]]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref> <ref>PMID:7852505</ref> <ref>PMID:9329347</ref> <ref>PMID:9589637</ref>
+== Function ==
+[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Grollman, A P]]
+[[Category: Pomyalov, S]]
 [[Category: Shoham, G]]
-[[Category: Grollman, A.P]]
+[[Category: Sidorenko, V S]]
-[[Category: Pomyalov, S]]
+[[Category: Aristolochic acid i]]
-[[Category: Sidorenko, V.S]]
+[[Category: Complex]]
+[[Category: High resolution]]
+[[Category: Human serum albumin]]
+[[Category: Transport protein]]