6mii: Difference between revisions

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~~'''Unreleased structure'''~~

The ~~entry 6mii~~ is ~~ON HOLD~~ ~~until Paper Publication~~

==Crystal structure of minichromosome maintenance protein MCM/DNA complex==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[6mii]] is a 7 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MII OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MII FirstGlance].

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=08T:[[[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-BIS(OXIDANYL)OXOLAN-2-YL]METHOXY-OXIDANYL-PHOSPHORYL]OXY-OXIDANYL-PHOSPHORYL]OXY-TRIS(FLUORANYL)BERYLLIUM'>08T</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/DNA_helicase DNA helicase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.12 3.6.4.12] </td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mii FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mii OCA], [http://pdbe.org/6mii PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mii RCSB], [http://www.ebi.ac.uk/pdbsum/6mii PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mii ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/MCM_SULSO MCM_SULSO]] Presumptive replicative helicase. Has ATPase and DNA helicase activities. The latter preferentially melts 5'-tailed oligonucleotides and is stimulated by the SSB protein (single-stranded DNA binding protein). The active ATPase sites in the MCM ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The helicase function is proposed to use a partially sequential mode of ATP hydrolysis; the complex appears to tolerate multiple catalytically inactive subunits.<ref>PMID:11821426</ref>

== References ==

__TOC__

</StructureSection>

[[Category: DNA helicase]]

[[Category: Large Structures]]

[[Category: Enemark, E J]]

[[Category: Epling, L B]]

[[Category: Meagher, M]]

[[Category: Aaa+]]

[[Category: Dna]]

[[Category: Helicase]]

[[Category: Hydrolase-dna complex]]

[[Category: Mcm]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6mii is ON HOLD  until Paper Publication
+==Crystal structure of minichromosome maintenance protein MCM/DNA complex==
+<StructureSection load='6mii' size='340' side='right'caption='[[6mii]], [[Resolution|resolution]] 3.15&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6mii]] is a 7 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MII OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MII FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=08T:[[[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-BIS(OXIDANYL)OXOLAN-2-YL]METHOXY-OXIDANYL-PHOSPHORYL]OXY-OXIDANYL-PHOSPHORYL]OXY-TRIS(FLUORANYL)BERYLLIUM'>08T</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_helicase DNA helicase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.12 3.6.4.12] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mii FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mii OCA], [http://pdbe.org/6mii PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mii RCSB], [http://www.ebi.ac.uk/pdbsum/6mii PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mii ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/MCM_SULSO MCM_SULSO]] Presumptive replicative helicase. Has ATPase and DNA helicase activities. The latter preferentially melts 5'-tailed oligonucleotides and is stimulated by the SSB protein (single-stranded DNA binding protein). The active ATPase sites in the MCM ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The helicase function is proposed to use a partially sequential mode of ATP hydrolysis; the complex appears to tolerate multiple catalytically inactive subunits.<ref>PMID:11821426</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: DNA helicase]]
+[[Category: Large Structures]]
+[[Category: Enemark, E J]]
+[[Category: Epling, L B]]
+[[Category: Meagher, M]]
+[[Category: Aaa+]]
+[[Category: Dna]]
+[[Category: Helicase]]
+[[Category: Hydrolase-dna complex]]
+[[Category: Mcm]]