6mnl: Difference between revisions
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==NMR solution structures of second bromodomain of BRD4 with FOXO3a peptide== | |||
<StructureSection load='6mnl' size='340' side='right' caption='[[6mnl]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6mnl]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MNL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MNL FirstGlance]. <br> | |||
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr> | |||
[[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mnl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mnl OCA], [http://pdbe.org/6mnl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mnl RCSB], [http://www.ebi.ac.uk/pdbsum/6mnl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mnl ProSAT]</span></td></tr> | ||
[[ | </table> | ||
== Disease == | |||
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Zeng, L]] | [[Category: Zeng, L]] | ||
[[Category: Zhou, M M]] | |||
[[Category: Akt]] | |||
[[Category: Brd4]] | |||
[[Category: Cdk6]] | |||
[[Category: Luminal breast cancer]] | |||
[[Category: Transcription]] | |||
Revision as of 07:01, 31 October 2018
NMR solution structures of second bromodomain of BRD4 with FOXO3a peptide
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