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==X-Ray structure of a CypA-Alisporivir complex at 1.5 angstrom resolution==
==X-Ray structure of a CypA-Alisporivir complex at 1.5 angstrom resolution==
<StructureSection load='5hsv' size='340' side='right' caption='[[5hsv]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
<StructureSection load='5hsv' size='340' side='right'caption='[[5hsv]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5hsv]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/African_green_monkey African green monkey]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HSV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HSV FirstGlance]. <br>
<table><tr><td colspan='2'>[[5hsv]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Chlorocebus_aethiops Chlorocebus aethiops] and [https://en.wikipedia.org/wiki/Tolypocladium_inflatum Tolypocladium inflatum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HSV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HSV FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=66E:'>66E</scene>, <scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene>, <scene name='pdbligand=BMT:4-METHYL-4-[(E)-2-BUTENYL]-4,N-METHYL-THREONINE'>BMT</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DAM:N-METHYL-ALPHA-BETA-DEHYDROALANINE'>DAM</scene>, <scene name='pdbligand=MLE:N-METHYLLEUCINE'>MLE</scene>, <scene name='pdbligand=MVA:N-METHYLVALINE'>MVA</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=66E:N-ethyl-L-valine'>66E</scene>, <scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene>, <scene name='pdbligand=BMT:4-METHYL-4-[(E)-2-BUTENYL]-4,N-METHYL-THREONINE'>BMT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DAM:N-METHYL-ALPHA-BETA-DEHYDROALANINE'>DAM</scene>, <scene name='pdbligand=MLE:N-METHYLLEUCINE'>MLE</scene>, <scene name='pdbligand=MVA:N-METHYLVALINE'>MVA</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PPIA, CYPA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9534 African green monkey])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5hsv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hsv OCA], [https://pdbe.org/5hsv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5hsv RCSB], [https://www.ebi.ac.uk/pdbsum/5hsv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5hsv ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hsv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hsv OCA], [http://pdbe.org/5hsv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hsv RCSB], [http://www.ebi.ac.uk/pdbsum/5hsv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hsv ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PPIA_CHLAE PPIA_CHLAE]] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.  
[https://www.uniprot.org/uniprot/PPIA_CHLAE PPIA_CHLAE] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Cyclophilin|Cyclophilin]]
*[[Cyclophilin 3D structures|Cyclophilin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: African green monkey]]
[[Category: Chlorocebus aethiops]]
[[Category: Peptidylprolyl isomerase]]
[[Category: Large Structures]]
[[Category: Bouckaert, J]]
[[Category: Tolypocladium inflatum]]
[[Category: Dujardin, M]]
[[Category: Bouckaert J]]
[[Category: Hanoulle, X]]
[[Category: Dujardin M]]
[[Category: Rucktooa, P]]
[[Category: Hanoulle X]]
[[Category: Cyclophilin ppia csa-derivative non-immunosuppressive]]
[[Category: Rucktooa P]]
[[Category: Isomerase]]
Retrieved from "https://proteopedia.org/5hsv"