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==Crystal structure of the Kelch domain of human KLHL17==
==Crystal structure of the Kelch domain of human KLHL17==
<StructureSection load='6hrl' size='340' side='right' caption='[[6hrl]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='6hrl' size='340' side='right'caption='[[6hrl]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6hrl]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HRL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HRL FirstGlance]. <br>
<table><tr><td colspan='2'>[[6hrl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HRL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6HRL FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hrl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hrl OCA], [http://pdbe.org/6hrl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hrl RCSB], [http://www.ebi.ac.uk/pdbsum/6hrl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hrl ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6hrl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hrl OCA], [https://pdbe.org/6hrl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6hrl RCSB], [https://www.ebi.ac.uk/pdbsum/6hrl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6hrl ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/KLH17_HUMAN KLH17_HUMAN]] Substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(KLHL17) mediates the ubiquitination and subsequenct degradation of GLUR6. May play a role in the actin-based neuronal function (By similarity).  
[https://www.uniprot.org/uniprot/KLH17_HUMAN KLH17_HUMAN] Substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(KLHL17) mediates the ubiquitination and subsequenct degradation of GLUR6. May play a role in the actin-based neuronal function (By similarity).
 
==See Also==
*[[Kelch-like protein 3D structures|Kelch-like protein 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Arrowsmith, F]]
[[Category: Homo sapiens]]
[[Category: Bountra, C]]
[[Category: Large Structures]]
[[Category: Bullock, A N]]
[[Category: Arrowsmith F]]
[[Category: Burgess-Brown, N]]
[[Category: Bountra C]]
[[Category: Chen, Z]]
[[Category: Bullock AN]]
[[Category: Delft, F von]]
[[Category: Burgess-Brown N]]
[[Category: Edwards, C H]]
[[Category: Chen Z]]
[[Category: Newman, J A]]
[[Category: Edwards CH]]
[[Category: Shrestha, L]]
[[Category: Newman JA]]
[[Category: Sorrell, F J]]
[[Category: Shrestha L]]
[[Category: Williams, E]]
[[Category: Sorrell FJ]]
[[Category: Actinfilin]]
[[Category: Williams E]]
[[Category: Cullin 3 e3 ligase substrate adaptor]]
[[Category: Von Delft F]]
[[Category: Homo sapien]]
[[Category: Kelch domain]]
[[Category: Ligase]]
[[Category: Ubiquitination]]
Retrieved from "https://proteopedia.org/6hrl"