2rcu: Difference between revisions

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[[Image:2rcu.gif|left|200px]]
[[Image:2rcu.gif|left|200px]]


{{Structure
<!--
|PDB= 2rcu |SIZE=350|CAPTION= <scene name='initialview01'>2rcu</scene>, resolution 1.78&Aring;
The line below this paragraph, containing "STRUCTURE_2rcu", creates the "Structure Box" on the page.
|SITE=
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
|LIGAND= <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=BUJ:(3R)-3-(HEXADECANOYLAMINO)-4-(TRIMETHYLAMMONIO)BUTANOATE'>BUJ</scene>
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Carnitine_O-palmitoyltransferase Carnitine O-palmitoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.21 2.3.1.21] </span>
or leave the SCENE parameter empty for the default display.
|GENE= Cpt2, Cpt-2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])
-->
|DOMAIN=
{{STRUCTURE_2rcu| PDB=2rcu  | SCENE= }}  
|RELATEDENTRY=[[2deb|2DEB]], [[2fw3|2FW3]], [[2fyo|2FYO]], [[2h4t|2H4T]]
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rcu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rcu OCA], [http://www.ebi.ac.uk/pdbsum/2rcu PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2rcu RCSB]</span>
}}


'''Crystal structure of rat carnitine palmitoyltransferase 2 in complex with r-3-(hexadecanoylamino)-4-(trimethylazaniumyl)butanoate'''
'''Crystal structure of rat carnitine palmitoyltransferase 2 in complex with r-3-(hexadecanoylamino)-4-(trimethylazaniumyl)butanoate'''
Line 31: Line 28:
[[Category: Rufer, A C.]]
[[Category: Rufer, A C.]]
[[Category: Thoma, R.]]
[[Category: Thoma, R.]]
[[Category: acetylation]]
[[Category: Acetylation]]
[[Category: acyltransferase]]
[[Category: Acyltransferase]]
[[Category: fatty acid metabolism]]
[[Category: Fatty acid metabolism]]
[[Category: inner membrane]]
[[Category: Inner membrane]]
[[Category: lipid metabolism]]
[[Category: Lipid metabolism]]
[[Category: membrane]]
[[Category: Membrane]]
[[Category: mitochondrial protein]]
[[Category: Mitochondrial protein]]
[[Category: mitochondrion]]
[[Category: Mitochondrion]]
[[Category: transferase]]
[[Category: Transferase]]
[[Category: transferase 04-mai-06 r]]
[[Category: Transferase 04-mai-06 r]]
[[Category: transit peptide]]
[[Category: Transit peptide]]
[[Category: transport]]
[[Category: Transport]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 16:39:22 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:58:56 2008''

Revision as of 13:39, 4 May 2008

File:2rcu.gif

Template:STRUCTURE 2rcu

Crystal structure of rat carnitine palmitoyltransferase 2 in complex with r-3-(hexadecanoylamino)-4-(trimethylazaniumyl)butanoate


Overview

The mitochondrial membrane-associated carnitine palmitoyltransferase system is a validated target for the treatment of type 2 diabetes mellitus. To further facilitate structure-based drug discovery, we determined the crystal structure of rat CPT-2 (rCPT-2) in complex with the substrate analogue palmitoyl-aminocarnitine at 1.8A resolution. Biochemical analyses revealed a strong effect of this compound on rCPT-2 activity and stability. Using a computational approach we examined the membrane association of rCPT-2. The protein interacts with the membrane as a functional monomer and the calculations confirm the presence of a membrane association domain that consists of layers of hydrophobic and positively charged residues.

About this Structure

2RCU is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Carnitine palmitoyltransferase 2: analysis of membrane association and complex structure with a substrate analog., Rufer AC, Lomize A, Benz J, Chomienne O, Thoma R, Hennig M, FEBS Lett. 2007 Jul 10;581(17):3247-52. Epub 2007 Jun 8. PMID:17585909 Page seeded by OCA on Sun May 4 16:39:22 2008

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