3a26: Difference between revisions

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==Crystal structure of P. horikoshii TYW2 in complex with MeSAdo==
==Crystal structure of P. horikoshii TYW2 in complex with MeSAdo==
<StructureSection load='3a26' size='340' side='right' caption='[[3a26]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='3a26' size='340' side='right'caption='[[3a26]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3a26]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/'pyrococcus_shinkaii' 'pyrococcus shinkaii']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A26 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3A26 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3a26]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/'pyrococcus_shinkaii' 'pyrococcus shinkaii']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A26 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3A26 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MTA:5-DEOXY-5-METHYLTHIOADENOSINE'>MTA</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MTA:5-DEOXY-5-METHYLTHIOADENOSINE'>MTA</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3a25|3a25]], [[3a27|3a27]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3a25|3a25]], [[3a27|3a27]]</div></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PH0793 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=53953 'Pyrococcus shinkaii'])</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PH0793 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=53953 'Pyrococcus shinkaii'])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3a26 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a26 OCA], [http://pdbe.org/3a26 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3a26 RCSB], [http://www.ebi.ac.uk/pdbsum/3a26 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3a26 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3a26 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a26 OCA], [https://pdbe.org/3a26 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3a26 RCSB], [https://www.ebi.ac.uk/pdbsum/3a26 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3a26 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TYW2_PYRHO TYW2_PYRHO]] S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe).[HAMAP-Rule:MF_01922]<ref>PMID:19717466</ref>   
[[https://www.uniprot.org/uniprot/TYW2_PYRHO TYW2_PYRHO]] S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe).[HAMAP-Rule:MF_01922]<ref>PMID:19717466</ref>   
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Pyrococcus shinkaii]]
[[Category: Pyrococcus shinkaii]]
[[Category: Large Structures]]
[[Category: Ishitani, R]]
[[Category: Ishitani, R]]
[[Category: Nishimasu, H]]
[[Category: Nishimasu, H]]