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ISSN 2310-6301 As life is more than 2D, Proteopedia helps to bridge the 3D relationships between function & structure of biomacromolecules
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Coronavirus Spike Protein Membrane Fusion by Eric Martz SARS-CoV-2 spike protein "spears" the host membrane with a fusion peptide and drags the virus envelope membrane transmembrane domain close to the host membrane, initiating fusion. This moves the virus RNA genome into the host cell, initiating infection. >>> Visit this page >>>	Molecular Sculpture by Eric Martz A historical review on sculptures and physical models of macromolecules. >>> Visit this page >>>	Interconversion of the specificities of human lysosomal enzymes associated with Fabry and Schindler diseases. IB Tomasic, MC Metcalf, AI Guce, NE Clark, SC Garman. J. Biol. Chem. 2010 doi: 10.1074/jbc.M110.118588 The human lysosomal enzymes α-galactosidase and α-N-acetylgalactosaminidase share 46% amino acid sequence identity and have similar folds. Using a rational protein engineering approach, we interconverted the enzymatic specificity of α-GAL and α-NAGAL. The engineered α-GAL retains the antigenicity but has acquired the enzymatic specificity of α-NAGAL. Conversely, the engineered α-NAGAL retains the antigenicity but has acquired the enzymatic specificity of the α-GAL enzyme. Comparison of the crystal structures of the designed enzyme to the wild-type enzymes shows that active sites superimpose well, indicating success of the rational design. The designed enzymes might be useful as non-immunogenic alternatives in enzyme replacement therapy for treatment of lysosomal storage disorders such as Fabry disease. >>> Visit this I3DC complement >>>	Touch-Sensitive Channel Touching stretches cell membranes, opening mechanosensitive ion channels, leading to sensation by the nervous system. Pictured is the transmembrane region of a similar channel in bacteria. When closed, the narrow opening is lined by hydrophobic amino acid sidechains, making it non-conductive to ions. >>> See more animations and explanation >>>
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