Insertase: Difference between revisions
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Michal Harel (talk | contribs) New page: <StructureSection load='4utq' size='340' side='right' caption='Cryo EM structure of E. coli insertase (grey) complex with membrane domain of ATP synthase (green) PDB code 4utq.' scene... |
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<StructureSection load='4utq' size='340' side='right' caption='Cryo EM structure of E. coli insertase (grey) complex with membrane domain of ATP synthase (green) PDB code [[4utq]].' scene=''> | <StructureSection load='4utq' size='340' side='right' caption='Cryo EM structure of E. coli insertase (grey) complex with membrane domain of ATP synthase (green) PDB code [[4utq]].' scene=''> | ||
'''Insertase''' (Ins) catalyzes the insertion of proteins into the prokaryotic plasma membrane. Ins interacts with its substrate in a groove-like structure at an ampiphilic protein-lipid interface allowing the transmembrane segments of the substrate to slide into the lipid bilayer<ref>PMID:27879020</ref>. | '''Insertase''' (Ins) catalyzes the insertion of proteins into the prokaryotic plasma membrane. Ins interacts with its substrate in a groove-like structure at an ampiphilic protein-lipid interface allowing the transmembrane segments of the substrate to slide into the lipid bilayer<ref>PMID:27879020</ref>. | ||
== Structural highlights == | == Structural highlights == | ||
E. Coli Ins (YidC) contains 6 transmembrane segments. Two of these segments was found to interact with a helical segments of a protein which is a candidate for insertion into a plasma membrane<ref>PMID:18996118</ref>. | |||
</StructureSection> | </StructureSection> | ||
Revision as of 08:12, 23 October 2018
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3D structures of insertase
Updated on 23-October-2018
5m5h, 3wvf - EcIns YidC - Escherichia coli - Cryo EM
3bs6 - EcIns YidC periplasmic domain
4utq - EcIns YidC + ATP synthase subunit C - Cryo EM
3wo7, 3wo6 - Ins YidC - Bacillus halodurans
4c4v - EcIns BamA reasidues 344-808
5ekq - Ins BamA + BamC + BamD + BamE
4k3b - Ins BamA - Neisseria gonorrhoeae
4k3c - Ins BamA - Haemophilus Ducreyi
5y82, 5y83 - Ins YidC (mutant) - Thermotoga maritima
