2rmj: Difference between revisions
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{{STRUCTURE_2rmj| PDB=2rmj | SCENE= }} | |||
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'''Solution structure of RIG-I C-terminal domain''' | '''Solution structure of RIG-I C-terminal domain''' | ||
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[[Category: Takahasi, K.]] | [[Category: Takahasi, K.]] | ||
[[Category: Yoneyama, M.]] | [[Category: Yoneyama, M.]] | ||
[[Category: | [[Category: Alternative splicing]] | ||
[[Category: | [[Category: Antiviral defense]] | ||
[[Category: | [[Category: Atp-binding]] | ||
[[Category: | [[Category: Cytoplasm]] | ||
[[Category: | [[Category: Helicase]] | ||
[[Category: | [[Category: Hydrolase]] | ||
[[Category: | [[Category: Immune response]] | ||
[[Category: | [[Category: Innate immunity]] | ||
[[Category: | [[Category: Interferon induction]] | ||
[[Category: | [[Category: Nucleotide-binding]] | ||
[[Category: | [[Category: Polymorphism]] | ||
[[Category: | [[Category: Rna binding protein]] | ||
[[Category: | [[Category: Rna-binding]] | ||
[[Category: | [[Category: Ubl conjugation]] | ||
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Revision as of 14:10, 4 May 2008
Solution structure of RIG-I C-terminal domain
Overview
A DExD/H protein, RIG-I, is critical in innate antiviral responses by sensing viral RNA. Here we show that RIG-I recognizes two distinct viral RNA patterns: double-stranded (ds) and 5'ppp single-stranded (ss) RNA. The binding of RIG-I with dsRNA or 5'ppp ssRNA in the presence of ATP produces a common structure, as suggested by protease digestion. Further analyses demonstrated that the C-terminal domain of RIG-I (CTD) recognizes these RNA patterns and CTD coincides with the autorepression domain. Structural analysis of CTD by NMR spectroscopy in conjunction with mutagenesis revealed that the basic surface of CTD with a characteristic cleft interacts with RIG-I ligands. Our results suggest that the bipartite structure of CTD regulates RIG-I on encountering viral RNA patterns.
About this Structure
2RMJ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Nonself RNA-sensing mechanism of RIG-I helicase and activation of antiviral immune responses., Takahasi K, Yoneyama M, Nishihori T, Hirai R, Kumeta H, Narita R, Gale M Jr, Inagaki F, Fujita T, Mol Cell. 2008 Feb 29;29(4):428-40. Epub 2008 Jan 31. PMID:18242112 Page seeded by OCA on Sun May 4 17:10:46 2008
Proteopedia Page Contributors and Editors (what is this?)
- Pages with broken file links
- Homo sapiens
- Single protein
- Fujita, T.
- Hirai, R.
- Inagaki, F.
- Jr., M Gale.
- Narita, R.
- Nihishori, T.
- Takahasi, K.
- Yoneyama, M.
- Alternative splicing
- Antiviral defense
- Atp-binding
- Cytoplasm
- Helicase
- Hydrolase
- Immune response
- Innate immunity
- Interferon induction
- Nucleotide-binding
- Polymorphism
- Rna binding protein
- Rna-binding
- Ubl conjugation
