6eht: Difference between revisions

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==Modulation of PCNA sliding surface by p15PAF suggests a suppressive mechanism for cisplatin-induced DNA lesion bypass by pol eta holoenzyme==
==Modulation of PCNA sliding surface by p15PAF suggests a suppressive mechanism for cisplatin-induced DNA lesion bypass by pol eta holoenzyme==
<StructureSection load='6eht' size='340' side='right' caption='[[6eht]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
<StructureSection load='6eht' size='340' side='right'caption='[[6eht]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6eht]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EHT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EHT FirstGlance]. <br>
<table><tr><td colspan='2'>[[6eht]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EHT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6EHT FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PCNA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6eht FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6eht OCA], [http://pdbe.org/6eht PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6eht RCSB], [http://www.ebi.ac.uk/pdbsum/6eht PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6eht ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6eht FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6eht OCA], [https://pdbe.org/6eht PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6eht RCSB], [https://www.ebi.ac.uk/pdbsum/6eht PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6eht ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/PCNA_HUMAN PCNA_HUMAN]] Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways. Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion.<ref>PMID:19443450</ref> <ref>PMID:18719106</ref>  [[http://www.uniprot.org/uniprot/PAF15_HUMAN PAF15_HUMAN]] PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with PCNA is disrupted, facilitating the interaction between monoubiquitinated PCNA and the translesion DNA synthesis DNA polymerase eta (POLH) at stalled replisomes, facilitating the bypass of replication-fork-blocking lesions. Also acts as a regulator of centrosome number.<ref>PMID:21673012</ref> <ref>PMID:23000965</ref> 
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Proliferating Cell Nuclear Antigen|Proliferating Cell Nuclear Antigen]]
*[[Proliferating cell nuclear antigen 3D structures|Proliferating cell nuclear antigen 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Barrera-Vilarmau, S]]
[[Category: Large Structures]]
[[Category: Biasio, A De]]
[[Category: Barrera-Vilarmau S]]
[[Category: Blanco, F J]]
[[Category: Blanco FJ]]
[[Category: Bressan, E]]
[[Category: Bressan E]]
[[Category: Crehuet, R]]
[[Category: Crehuet R]]
[[Category: Maga, G]]
[[Category: De Biasio A]]
[[Category: March, M De]]
[[Category: De March M]]
[[Category: Mentegari, E]]
[[Category: Maga G]]
[[Category: Merino, N]]
[[Category: Mentegari E]]
[[Category: Onesti, S]]
[[Category: Merino N]]
[[Category: Dna binding protein]]
[[Category: Onesti S]]
[[Category: Human pcna p15 dna macro complex]]
[[Category: Structural analysis]]
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