3aaw: Difference between revisions

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==Crystal structure of aspartate kinase from Corynebacterium glutamicum in complex with lysine and threonine==
==Crystal structure of aspartate kinase from Corynebacterium glutamicum in complex with lysine and threonine==
<StructureSection load='3aaw' size='340' side='right' caption='[[3aaw]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='3aaw' size='340' side='right'caption='[[3aaw]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3aaw]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_glutamicus"_kinoshita_et_al._1958 "micrococcus glutamicus" kinoshita et al. 1958] and [http://en.wikipedia.org/wiki/'corynebacterium_crenatum' 'corynebacterium crenatum']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AAW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3AAW FirstGlance]. <br>
<table><tr><td colspan='2'>[[3aaw]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/"micrococcus_glutamicus"_kinoshita_et_al._1958 "micrococcus glutamicus" kinoshita et al. 1958] and [https://en.wikipedia.org/wiki/'corynebacterium_crenatum' 'corynebacterium crenatum']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AAW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AAW FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LYS:LYSINE'>LYS</scene>, <scene name='pdbligand=THR:THREONINE'>THR</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LYS:LYSINE'>LYS</scene>, <scene name='pdbligand=THR:THREONINE'>THR</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ab4|3ab4]], [[3ab2|3ab2]], [[2dtj|2dtj]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3ab4|3ab4]], [[3ab2|3ab2]], [[2dtj|2dtj]]</div></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">lysC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1718 "Micrococcus glutamicus" Kinoshita et al. 1958]), lysC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=168810 'Corynebacterium crenatum'])</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">lysC ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1718 "Micrococcus glutamicus" Kinoshita et al. 1958]), lysC ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=168810 'Corynebacterium crenatum'])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aspartate_kinase Aspartate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.2.4 2.7.2.4] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Aspartate_kinase Aspartate kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.2.4 2.7.2.4] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3aaw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3aaw OCA], [http://pdbe.org/3aaw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3aaw RCSB], [http://www.ebi.ac.uk/pdbsum/3aaw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3aaw ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3aaw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3aaw OCA], [https://pdbe.org/3aaw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3aaw RCSB], [https://www.ebi.ac.uk/pdbsum/3aaw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3aaw ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/AK_CORGL AK_CORGL]] Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids lysine, threonine, isoleucine and methionine.<ref>PMID:17350037</ref> <ref>PMID:20573952</ref>   
[[https://www.uniprot.org/uniprot/AK_CORGL AK_CORGL]] Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids lysine, threonine, isoleucine and methionine.<ref>PMID:17350037</ref> <ref>PMID:20573952</ref>   
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Corynebacterium crenatum]]
[[Category: Corynebacterium crenatum]]
[[Category: Aspartate kinase]]
[[Category: Aspartate kinase]]
[[Category: Large Structures]]
[[Category: Kuzuyama, T]]
[[Category: Kuzuyama, T]]
[[Category: Nishiyama, M]]
[[Category: Nishiyama, M]]
Retrieved from "https://proteopedia.org/3aaw"