6ht9: Difference between revisions
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==Mouse fetuin-B in complex with crayfish astacin== | |||
<StructureSection load='6ht9' size='340' side='right'caption='[[6ht9]], [[Resolution|resolution]] 3.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6ht9]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Astacus_astacus Astacus astacus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HT9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HT9 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
[[Category: | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Astacin Astacin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.21 3.4.24.21] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ht9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ht9 OCA], [http://pdbe.org/6ht9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ht9 RCSB], [http://www.ebi.ac.uk/pdbsum/6ht9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ht9 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/ASTA_ASTAS ASTA_ASTAS]] This protease prefers to cleave in front of small aliphatic residues (P1'). The presence of Lys or Arg in the P1 and P2 position yields high-turnover substrates. In the P3 position the enzyme prefers Pro > Val > Leu > Ala > Gly. [[http://www.uniprot.org/uniprot/FETUB_MOUSE FETUB_MOUSE]] Protease inhibitor required for egg fertilization. Required to prevent premature zona pellucida hardening before fertilization, probably by inhibiting the protease activity of ASTL, a protease that mediates the cleavage of ZP2 and triggers zona pellucida hardening.<ref>PMID:23562279</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Astacin]] | |||
[[Category: Astacus astacus]] | |||
[[Category: Large Structures]] | |||
[[Category: Cuppari, A]] | |||
[[Category: Gomis-Ruth, F X]] | |||
[[Category: Goulas, T]] | |||
[[Category: Guevara, T]] | |||
[[Category: Cystatin]] | |||
[[Category: Fetuin]] | |||
[[Category: Hydrolase]] | |||
[[Category: Metallopeptidase]] | |||
[[Category: Ovastacin inhibitor]] | |||
[[Category: Peptidase inhibitor]] | |||
Revision as of 12:02, 13 March 2019
Mouse fetuin-B in complex with crayfish astacin
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