6hyn: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6hyn ~~is ON HOLD~~

==Structure of ATG13 LIR motif bound to GABARAP==

~~Authors~~: ~~Mouilleron, S~~.~~, Wirth, M~~.~~, Zhang, W~~.~~, O~~'~~Reilly~~, N., ~~Tooze~~, S., ~~Johansen, T~~.~~, Razi, M~~., ~~Nyoni, L~~.~~, Joshi, D~~.

== Structural highlights ==

<table><tr><td colspan='2'>[[6hyn]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HYN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HYN FirstGlance]. <br>

~~Description~~: ~~Structure~~ of ATG13 ~~LIR motif bound to GABARAP~~

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hyn OCA], [http://pdbe.org/6hyn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hyn RCSB], [http://www.ebi.ac.uk/pdbsum/6hyn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hyn ProSAT]</span></td></tr>

[[Category: ~~Unreleased~~ Structures]]

</table>

== Function ==

[[http://www.uniprot.org/uniprot/ATG13_HUMAN ATG13_HUMAN]] Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.<ref>PMID:19287211</ref> <ref>PMID:19211835</ref> <ref>PMID:19225151</ref> <ref>PMID:21855797</ref> <ref>PMID:18936157</ref> <ref>PMID:21795849</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Johansen, T]]

[[Category: Joshi, D]]

[[Category: Mouilleron, S]]

[[Category: Nyoni, L]]

[[Category: Razi, M]]

[[Category: ~~Johansen, T]]~~

[[Category: Reilly, N O]]

~~[[Category: Zhang, W]]~~

~~[[Category: Nyoni, L]]~~

~~[[Category: O'~~Reilly, N]]

[[Category: Tooze, S]]

~~[[Category: Mouilleron, S]]~~

[[Category: Wirth, M]]

[[Category: Zhang, W]]

[[Category: Atg8]]

[[Category: Autophagy]]

[[Category: Lir]]

[[Category: Signaling protein]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6hyn is ON HOLD
+==Structure of ATG13 LIR motif bound to GABARAP==
+<StructureSection load='6hyn' size='340' side='right'caption='[[6hyn]], [[Resolution|resolution]] 1.14&Aring;' scene=''>
-Authors: Mouilleron, S., Wirth, M., Zhang, W., O'Reilly, N., Tooze, S., Johansen, T., Razi, M., Nyoni, L., Joshi, D.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6hyn]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HYN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HYN FirstGlance]. <br>
-Description: Structure of ATG13 LIR motif bound to GABARAP
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hyn OCA], [http://pdbe.org/6hyn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hyn RCSB], [http://www.ebi.ac.uk/pdbsum/6hyn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hyn ProSAT]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/ATG13_HUMAN ATG13_HUMAN]] Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.<ref>PMID:19287211</ref> <ref>PMID:19211835</ref> <ref>PMID:19225151</ref> <ref>PMID:21855797</ref> <ref>PMID:18936157</ref> <ref>PMID:21795849</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Johansen, T]]
 [[Category: Joshi, D]]
+[[Category: Mouilleron, S]]
+[[Category: Nyoni, L]]
 [[Category: Razi, M]]
-[[Category: Johansen, T]]
+[[Category: Reilly, N O]]
-[[Category: Zhang, W]]
-[[Category: Nyoni, L]]
-[[Category: O'Reilly, N]]
 [[Category: Tooze, S]]
-[[Category: Mouilleron, S]]
 [[Category: Wirth, M]]
+[[Category: Zhang, W]]
+[[Category: Atg8]]
+[[Category: Autophagy]]
+[[Category: Lir]]
+[[Category: Signaling protein]]