6mv2: Difference between revisions
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==2.05A resolution structure of the CS-b5R domains of human Ncb5or (NADP+ form)== | |||
<StructureSection load='6mv2' size='340' side='right'caption='[[6mv2]], [[Resolution|resolution]] 2.05Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6mv2]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MV2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MV2 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr> | |||
[[Category: | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cytochrome-b5_reductase Cytochrome-b5 reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.6.2.2 1.6.2.2] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mv2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mv2 OCA], [http://pdbe.org/6mv2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mv2 RCSB], [http://www.ebi.ac.uk/pdbsum/6mv2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mv2 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/NB5R4_HUMAN NB5R4_HUMAN]] NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS). Reduces a variety of substrates in vitro, such as cytochrome c, feericyanide and methemoglobin. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Cytochrome-b5 reductase]] | |||
[[Category: Large Structures]] | |||
[[Category: Battaile, K P]] | |||
[[Category: Benson, D R]] | |||
[[Category: Cooper, A]] | |||
[[Category: Gao, P]] | |||
[[Category: Lovell, S]] | |||
[[Category: Mehzabeen, N]] | |||
[[Category: Zhu, H]] | |||
[[Category: Electron transfer]] | |||
[[Category: Endoplasmic reticulum]] | |||
[[Category: Flavoprotein]] | |||
[[Category: Heme]] | |||
[[Category: Iron]] | |||
[[Category: Metal-binding]] | |||
[[Category: Ncb5or]] | |||
[[Category: Oxidoreductase]] | |||
[[Category: Redox]] | |||
